Brain PET Imaging: Value for Understanding the Pathophysiology of HIV-associated Neurocognitive Disorder (HAND)
- PMID: 30778853
- DOI: 10.1007/s11904-019-00419-8
Brain PET Imaging: Value for Understanding the Pathophysiology of HIV-associated Neurocognitive Disorder (HAND)
Abstract
Purpose of review: The purpose of this review is to summarize recent developments in PET imaging of neuropathologies underlying HIV-associated neurocognitive dysfunction (HAND). We concentrate on the recent post antiretroviral era (ART), highlighting clinical and preclinical brain PET imaging studies.
Recent findings: In the post ART era, PET imaging has been used to better understand perturbations of glucose metabolism, neuroinflammation, the function of neurotransmitter systems, and amyloid/tau protein deposition in the brains of HIV-infected patients and HIV animal models. Preclinical and translational findings from those studies shed a new light on the complex pathophysiology underlying HAND. The molecular imaging capabilities of PET in neuro-HIV are great complements for structural imaging modalities. Recent and future PET imaging studies can improve our understanding of neuro-HIV and provide biomarkers of disease progress that could be used as surrogate endpoints in the evaluation of the effectiveness of potential neuroprotective therapies.
Keywords: Amyloid deposition; Brain PET imaging; HIV; HIV-associated neurocognitive disorder (HAND); Inflammation; Neurotransmitters.
Similar articles
-
PET brain imaging in HIV-associated neurocognitive disorders (HAND) in the era of combination antiretroviral therapy.Eur J Nucl Med Mol Imaging. 2017 May;44(5):895-902. doi: 10.1007/s00259-016-3602-3. Epub 2017 Jan 5. Eur J Nucl Med Mol Imaging. 2017. PMID: 28058461 Review.
-
Regional brain distribution of translocator protein using [(11)C]DPA-713 PET in individuals infected with HIV.J Neurovirol. 2014 Jun;20(3):219-32. doi: 10.1007/s13365-014-0239-5. Epub 2014 Feb 25. J Neurovirol. 2014. PMID: 24567030 Free PMC article.
-
Molecular Imaging of Neuroinflammation in HIV.J Neuroimmune Pharmacol. 2019 Mar;14(1):9-15. doi: 10.1007/s11481-018-9823-4. Epub 2018 Dec 5. J Neuroimmune Pharmacol. 2019. PMID: 30515624 Free PMC article. Review.
-
Molecular imaging of dementia.Psychogeriatrics. 2012 Jun;12(2):106-14. doi: 10.1111/j.1479-8301.2012.00409.x. Psychogeriatrics. 2012. PMID: 22712644 Review.
-
Imaging studies of the HIV-infected brain.Handb Clin Neurol. 2018;152:229-264. doi: 10.1016/B978-0-444-63849-6.00018-9. Handb Clin Neurol. 2018. PMID: 29604980 Review.
Cited by
-
Cardiovascular Disease, Brain Glucose Metabolism, and Neurocognitive Decline in People With Human Immunodeficiency Virus.Open Forum Infect Dis. 2024 Sep 20;11(10):ofae552. doi: 10.1093/ofid/ofae552. eCollection 2024 Oct. Open Forum Infect Dis. 2024. PMID: 39371364 Free PMC article.
-
Altered Gray Matter Volume and Functional Connectivity in Human Immunodeficiency Virus-Infected Adults.Front Neurosci. 2020 Dec 3;14:601063. doi: 10.3389/fnins.2020.601063. eCollection 2020. Front Neurosci. 2020. PMID: 33343289 Free PMC article.
-
Effects of SRI-32743, a Novel Quinazoline Structure-Based Compound, on HIV-1 Tat and Cocaine Interaction with Norepinephrine Transporter.Int J Mol Sci. 2024 Jul 18;25(14):7881. doi: 10.3390/ijms25147881. Int J Mol Sci. 2024. PMID: 39063123 Free PMC article.
-
Microglial Cells: The Main HIV-1 Reservoir in the Brain.Front Cell Infect Microbiol. 2019 Oct 24;9:362. doi: 10.3389/fcimb.2019.00362. eCollection 2019. Front Cell Infect Microbiol. 2019. PMID: 31709195 Free PMC article. Review.
-
1H-NMR metabolomics investigation of CSF from children with HIV reveals altered neuroenergetics due to persistent immune activation.Front Neurosci. 2024 Apr 30;18:1270041. doi: 10.3389/fnins.2024.1270041. eCollection 2024. Front Neurosci. 2024. PMID: 38745940 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials