Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Feb;16(1):66-75.
doi: 10.1007/s11904-019-00419-8.

Brain PET Imaging: Value for Understanding the Pathophysiology of HIV-associated Neurocognitive Disorder (HAND)

Affiliations
Review

Brain PET Imaging: Value for Understanding the Pathophysiology of HIV-associated Neurocognitive Disorder (HAND)

Sanhita Sinharay et al. Curr HIV/AIDS Rep. 2019 Feb.

Abstract

Purpose of review: The purpose of this review is to summarize recent developments in PET imaging of neuropathologies underlying HIV-associated neurocognitive dysfunction (HAND). We concentrate on the recent post antiretroviral era (ART), highlighting clinical and preclinical brain PET imaging studies.

Recent findings: In the post ART era, PET imaging has been used to better understand perturbations of glucose metabolism, neuroinflammation, the function of neurotransmitter systems, and amyloid/tau protein deposition in the brains of HIV-infected patients and HIV animal models. Preclinical and translational findings from those studies shed a new light on the complex pathophysiology underlying HAND. The molecular imaging capabilities of PET in neuro-HIV are great complements for structural imaging modalities. Recent and future PET imaging studies can improve our understanding of neuro-HIV and provide biomarkers of disease progress that could be used as surrogate endpoints in the evaluation of the effectiveness of potential neuroprotective therapies.

Keywords: Amyloid deposition; Brain PET imaging; HIV; HIV-associated neurocognitive disorder (HAND); Inflammation; Neurotransmitters.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Nat Methods. 2015 May;12(5):427-32 - PubMed
    1. Mol Neurodegener. 2014 Dec 18;9:58 - PubMed
    1. Elife. 2017 Feb 15;6: - PubMed
    1. J Neuropathol Exp Neurol. 1997 Nov;56(11):1262-8 - PubMed
    1. J Neurovirol. 2015 Apr;21(2):148-58 - PubMed

MeSH terms

LinkOut - more resources