Review
doi: 10.1242/jcs.1988.supplement_10.2.
Multi-lineage 'stem' cells in the mammalian embryo
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- PMID: 3077932
- DOI: 10.1242/jcs.1988.supplement_10.2
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Review
Multi-lineage 'stem' cells in the mammalian embryo
J Cell Sci Suppl.
1988.
Abstract
The term 'stem' cell has acquired a rather more restricted meaning in cell biology than in embryology as a result of studies on the growth kinetics of renewing tissues in mature organisms. It is normally used in an embryological context as a synonym for 'progenitor' cell. Methods of establishing the existence of multi-lineage progenitor cells in mammals are examined briefly before the occurrence and properties of such cells in both embryonic and extra-embryonic tissues of the mouse conceptus are reviewed. Various attributes of 'stem' cells that can be obtained from outgrowths of blastocysts in vitro are also discussed.
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