Review
doi: 10.1242/jcs.1988.supplement_10.13.
Tumour suppressor genes
Affiliations
- PMID: 3077935
- DOI: 10.1242/jcs.1988.supplement_10.13
Item in Clipboard
Review
Tumour suppressor genes
J Cell Sci Suppl.
1988.
Abstract
Genes that can inhibit the expression of the tumorigenic phenotype have been detected by the fusion of normal and malignant cells, the phenotypic reversion of in vitro transformants, the induction of terminal differentiation of malignant cell lineages, the loss of 'recessive cancer genes', the discovery of regulatory sequences in the immediate vicinity of certain oncogenes, and the inhibition of tumour growth by normal cell products. Such tumour suppressor genes will probably turn out to be as, if not more, diversified as the oncogenes. Consideration of both kinds of genes may reveal common or interrelated functional properties.
Similar articles
-
The approaching era of the tumor suppressor genes.Science. 1987 Dec 11;238(4833):1539-45. doi: 10.1126/science.3317834. Science. 1987. PMID: 3317834 Review.
-
Onco-suppressor genes and their involvement in cancer (review).Anticancer Res. 1988 Sep-Oct;8(5A):873-9. Anticancer Res. 1988. PMID: 3052259 Review.
-
Transformation effector and suppressor genes.J Cell Biochem. 1991 Jul;46(3):199-205. doi: 10.1002/jcb.240460303. J Cell Biochem. 1991. PMID: 1774222 Review.
-
Onco-suppressor genes in human cancer.Tumori. 1989 Aug 31;75(4):329-36. doi: 10.1177/030089168907500406. Tumori. 1989. PMID: 2573189 Review.
-
Tumour suppressor genes: oncogenesis update.Histopathology. 1989 Jul;15(1):1-9. doi: 10.1111/j.1365-2559.1989.tb03037.x. Histopathology. 1989. PMID: 2504658 Review.
Cited by
-
Reflections on the pathogenesis of diseases caused by the acute avian leukosis/sarcoma viruses with special reference to avian erythroblastosis.Vet Res Commun. 1994;18(5):397-415. doi: 10.1007/BF01839290. Vet Res Commun. 1994. PMID: 7863611 Review.
-
Biochemical markers associated with the stages of promotion and progression during hepatocarcinogenesis in the rat.Environ Health Perspect. 1991 Jun;93:181-9. doi: 10.1289/ehp.9193181. Environ Health Perspect. 1991. PMID: 1723043 Free PMC article. Review.
-
Molecular mechanisms of cancer.West J Med. 1991 Nov;155(5):505-14. West J Med. 1991. PMID: 1815390 Free PMC article. Review.
-
ras transfection and expression does not induce progression from tumorigenicity to metastatic ability in mouse LTA cells.Clin Exp Metastasis. 1990 Sep-Oct;8(5):417-31. doi: 10.1007/BF00058153. Clin Exp Metastasis. 1990. PMID: 1697227
-
Reflections on viruses and cancer.Vet Res Commun. 1994;18(1):43-61. doi: 10.1007/BF01839260. Vet Res Commun. 1994. PMID: 8091640 Review.