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Review
. 1988;6(3-4):265-74.
doi: 10.1515/dmdi.1988.6.3-4.265.

alpha-Amanitin: a possible suicide substrate-like toxin involving the sulphoxide moiety of the bridged cyclopeptide

D Michelot  1 , R Labia
Affiliations
Review

alpha-Amanitin: a possible suicide substrate-like toxin involving the sulphoxide moiety of the bridged cyclopeptide

D Michelot et al. Drug Metabol Drug Interact. 1988.

Abstract

The highly hepatotoxic natural compound, alpha-amanitin, is noteworthy for its uncommon properties: high and specific affinity for the enzyme RNA polymerase type II, and, furthermore, high potency, severity and irreversibility of the poisoning. Considering the structural uniqueness of the tryptathionine bridge bearing a sulphoxide function, a few mechanistic and biochemical observations suggest that an enzyme-induced process may underlie the characteristics of the poisoning evolution which leads to the cytolysis of the hepatocytes.

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