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Comment
. 2019 Feb 19;50(2):275-278.
doi: 10.1016/j.immuni.2019.01.015.

Butyrate Makes Macrophages "Go Nuclear" against Bacterial Pathogens

Lior Lobel  1 , Wendy S Garrett  2
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Free article
Comment

Butyrate Makes Macrophages "Go Nuclear" against Bacterial Pathogens

Lior Lobel et al. Immunity. .
Free article

Abstract

Butyrate is a microbial metabolite with pleiotropic effects. Schulthess et al. (2019) report that butyrate preconditioning of macrophages enhances their anti-bacterial preparedness by inducing anti-microbial proteins that restrict bacterial growth. This study augments understanding of how microbial metabolites shape host defense.

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  • The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages.
    Schulthess J, Pandey S, Capitani M, Rue-Albrecht KC, Arnold I, Franchini F, Chomka A, Ilott NE, Johnston DGW, Pires E, McCullagh J, Sansom SN, Arancibia-Cárcamo CV, Uhlig HH, Powrie F. Schulthess J, et al. Immunity. 2019 Feb 19;50(2):432-445.e7. doi: 10.1016/j.immuni.2018.12.018. Epub 2019 Jan 23. Immunity. 2019. PMID: 30683619 Free PMC article.

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