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Comment
. 2019 Feb 19;50(2):280-282.
doi: 10.1016/j.immuni.2019.01.016.

Live or Let Die: T Cell Survival in Cancer Immunotherapy

Janne Ruotsalainen  1 , Thomas Tüting  2
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Live or Let Die: T Cell Survival in Cancer Immunotherapy

Janne Ruotsalainen et al. Immunity. .
Free article

Abstract

Combination immune checkpoint blockade targeting CTLA-4 and PD-1 is thought to reinvigorate exhausted T cells better than monotherapies. In this issue of Immunity, Pai et al. (2019) show that, in the setting of low tumor burden, this combination regimen promotes interferon-γ-dependent T cell hyperactivation and death and thus favors tumor progression.

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