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Comment
. 2019 Feb 19;50(2):285-287.
doi: 10.1016/j.immuni.2019.01.018.

The Secret Life of IgE-Producing Cells

Carlos J Aranda  1 , Maria A Curotto de Lafaille  2
Affiliations
Comment

The Secret Life of IgE-Producing Cells

Carlos J Aranda et al. Immunity. .

Abstract

IgE antibodies are essential mediators of allergies. In a recent study in Science, Croote et al. (2018) characterize IgE cells isolated from individuals allergic to peanuts. Their findings provide insight into the differentiation of IgE cells in humans and have implications for our understanding of allergic disease.

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Figures

Figure 1.
Figure 1.. Model for the Formation of High-Affinity Peanut-Specific IgE in Peanut Allergy
The development of peanut allergy in humans (represented here by individuals A and B) involves a GC reaction and the differentiation of memory B cells containing high-affinity clones. During re-exposure to peanut antigens, high-affinity memory B cell clones presumably of the IgG type undergo class-switch recombination to IgE and plasma cell differentiation. Croote et al. (2018) described that in peanut-allergic individuals, most circulating IgE cells are affinity matured plasmablasts and that unrelated individuals harbor convergent and cross-reactive IgE clones that bind the disease-relevant peanut allergens Ara h2 and Ara h1 with high affinity. Their findings are represented in the context of a current model of IgE cell differentiation.
See this image and copyright information in PMC

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