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Review
. 2019 Apr;35(2):375-388.
doi: 10.1016/j.ccc.2018.11.012. Epub 2019 Jan 24.

Thyroid Hormones in Critical Illness

Matthew J Maiden  1 , David J Torpy  2
Affiliations
Review

Thyroid Hormones in Critical Illness

Matthew J Maiden et al. Crit Care Clin. 2019 Apr.

Abstract

Thyroid hormone is integral for normal function, yet during illness, circulating levels of the most active form (triiodothyronine [T3]) decline. Whether this is an adaptive response in critical illness or contributes to progressive disease has remained controversial. This review outlines the basis of thyroid hormone changes during critical illness and considers the evidence regarding T3 replacement.

Keywords: Critical illness; Low T3 syndrome; Non-thyroidal illness syndrom; Sick euthyroid; Thyroid hormone; Triiodothyronine.

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