Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2019 Feb;41(2):84-89.
doi: 10.1055/s-0038-1676509. Epub 2019 Feb 20.

Pethidine in Low Doses versus Dipyrone for Pain Relief in Labor: A Randomized Controlled Trial

Rogevando Rodrigues Nunes  1 , André Montenegro Primo  1
Affiliations
Randomized Controlled Trial

Pethidine in Low Doses versus Dipyrone for Pain Relief in Labor: A Randomized Controlled Trial

Rogevando Rodrigues Nunes et al. Rev Bras Ginecol Obstet. 2019 Feb.

Abstract
in English, Portuguese

Objective: To compare low doses of pethidine with dipyrone in labor analgesia.

Methods: In a randomized prospective study conducted by Universidade de Fortaleza, in the state of Ceará, Brazil, between May and December 2016, 200 full-term parturients, with very painful uterine contractions and exhibiting uterine cervix dilatation ≥ 5 cm, were selected to receive a single intravenous dose of either 0.25 mg/kg of pethidine (n = 100) or of 25 mg/kg of dipyrone (n = 100). Pain was assessed using the visual analogue scale. The data were analyzed using the Student t-test, the chi-square test and the likelihood ratio.

Results: There was a significant improvement in pain in 35% of the parturients. Both drugs presented a similar analgesic effect 1 hour after the intervention (p = 0.692). There was no analgesic effect during the evaluation of the second hour after the intervention with pethidine or dipyrone. There were no adverse effects, such as maternal drowsiness, nausea or vomiting, related to the drugs used.

Conclusion: Pethidine in low doses and dipyrone presented equivalent analgesia during labor.

Public registry of clinical trials: RBR-4hsyy4.

Objetivo: Comparar doses baixas de petidina com dipirona na analgesia de parto. MéTODOS: Em um estudo prospectivo randomizado realizado pela Universidade de Fortaleza, Ceará, Brasil, entre maio e dezembro de 2016, 200 parturientes a termo, com contrações uterinas muito dolorosas e apresentando dilatação do colo uterino ≥ 5 cm, foram selecionadas para receber dose única intravenosa de 0,25 mg/kg de petidina (n = 100) ou 25 mg/kg de dipirona (n = 100). A dor foi avaliada pela escala visual analógica. Os dados foram analisados por meio dos testes t de Student, qui-quadrado e razão de verossimilhança.

Resultados: Houve melhora significativa da dor em 35% das parturientes. Ambas as drogas apresentaram efeito analgésico semelhante 1 hora após a intervenção (p = 0.692). Inexistiu efeito analgésico durante a avaliação da segunda hora após a intervenção com a petidina ou com a dipirona. Não houve efeitos adversos, como sonolência, náuseas ou vômitos maternos, relacionados aos medicamentos utilizados. CONCLUSãO: A petidina em doses baixas e a dipirona apresentaram analgesia equivalente durante o trabalho de parto. REGISTRO PúBLICO DE TESTES CLíNICOS: RBR-4hsyy4.

PubMed Disclaimer

Conflict of interest statement

The authors have none to declare.

Figures

Fig. 1
Fig. 1
Flow chart of the participants throughout the study.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Jasiecka A, Maślanka T, Jaroszewski J J.Pharmacological characteristics of metamizole Pol J Vet Sci 20141701207–214.. Doi: 10.2478/pjvs-2014-0030 - PubMed
    1. Labor S, Maguire S.The pain of labour Rev Pain 200820215–19.. Doi: 10.1177/204946370800200205 - PMC - PubMed
    1. Stramrood C AI, Doornbos B, Wessel I, et al. Fathers with PTSD and depression in pregnancies complicated by preterm preeclampsia or PPROM Arch Gynecol Obstet 201328704653–661.. Doi: 10.1007/s00404-012-2611-0 - PubMed
    1. Betrán A P, Ye J, Moller A B, Zhang J, Gülmezoglu A M, Torloni M R.The increasing trend in caesarean section rates: global, regional and national estimates: 1990–2014 PLoS One 20161102e0148343. Doi: 10.1371/journal.pone.0148343 - PMC - PubMed
    1. Reena K HB, Afzal M, Mishra A K, Paul A.Labor epidural analgesia: past, present and future Indian J Pain 20142871–81.. Doi: 10.4103/0970-5333.132843

Publication types

LinkOut - more resources