Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Feb;10(1):85-94.
doi: 10.21037/jgo.2018.10.06.

Gastric squamous cell carcinoma and gastric adenosquamous carcinoma, clinical features and outcomes of rare clinical entities: a National Cancer Database (NCDB) analysis

Mehmet Akce  1 , Renjian Jiang  2 , Olatunji B Alese  1 , Walid L Shaib  1 , Christina Wu  1 , Madhusmita Behera  2 , Bassel F El-Rayes  1
Affiliations

Gastric squamous cell carcinoma and gastric adenosquamous carcinoma, clinical features and outcomes of rare clinical entities: a National Cancer Database (NCDB) analysis

Mehmet Akce et al. J Gastrointest Oncol. 2019 Feb.

Abstract

Background: Gastric squamous cell carcinoma (GSCC) and gastric adenosquamous carcinoma (GASC) comprise less than 2% of gastric cancers. The current knowledge about clinical presentation, treatment modalities and outcomes of GSCC and GASC is limited. The aim of this study is to characterize the clinicopathological features, treatment modalities, and outcomes of GSCC and GASC in comparison to gastric adenocarcinoma (GAC) in National Cancer Database (NCDB).

Methods: Patients with GSCC, GASC and GAC between 2004 and 2013 were identified using ICD-O-3 histology and topography codes 8070/3, 8560/3, 8140/3 and C16.0-9. Univariate, and multivariate analysis were performed, and Kaplan-Meier curves was used to compare survival based on histological subtype.

Results: A total of 61,215 patients were identified, 836 (1.4%) GSCC, 327 (0.5%) GASC, 60,052 (98.1%) GAC between 2004 and 2013, in which 77.4% was Caucasian and 68.7% was male, 46.6% of tumors were in gastric cardia and 13.7% in gastric antrum. Neoadjuvant and adjuvant chemotherapy was administered in 11.2%, 14.1%, 8.9% vs. 2.9%, 11.9%, 9.5% for GSCC, GASC, GAC. Surgery was performed in 26.0%, 54.4%, 45.2% of GSCC, GASC, GAC. Radiotherapy was administered in 48.1%, 37.6%, 31.6% of GSCC, GASC, GAC. Median overall survival was 8.9, 9.9 and 13.2 months for GSCC, GASC, GAC. On multivariate analysis squamous cell (HR =1.14; 95% CI, 1.06-1.24, P=0.001) and adenosquamous cell histology (HR =1.52; 95% CI, 1.35-1.73, P<0.001) was associated with worse survival compared to adenocarcinoma.

Conclusions: GSCC and GASC have poorer survival outcomes compared to GAC. Less patients with GSCC received surgery and adjuvant chemotherapy, more patients with GSCC received radiation therapy.

Keywords: Gastric cancer; gastric adenocarcinoma (GAC); gastric adenosquamous carcinoma (GASC); gastric squamous cell carcinoma (GSCC); rare gastric cancers.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Kaplan-Meier survival curves by histology.
See this image and copyright information in PMC

References

    1. Dong C, Jiang M, Tan Y, et al. The clinicopathological features and prognostic factors of gastric squamous cell carcinoma. Medicine (Baltimore) 2016;95:e4720. 10.1097/MD.0000000000004720 - DOI - PMC - PubMed
    1. Richman DM, Tirumani SH, Hornick JL, et al. Beyond gastric adenocarcinoma: Multimodality assessment of common and uncommon gastric neoplasms. Abdom Radiol (NY) 2017;42:124-40. 10.1007/s00261-016-0901-x - DOI - PMC - PubMed
    1. Hwang SH, Lee JH, Kim K, et al. Primary squamous cell carcinoma of the stomach: A case report. Oncol Lett 2014;8:2122-4. 10.3892/ol.2014.2492 - DOI - PMC - PubMed
    1. Tokuhara K, Nakano T, Inoue K, et al. Primary squamous cell carcinoma in the gastric remnant. Surg Today 2012;42:666-9. 10.1007/s00595-012-0144-6 - DOI - PubMed
    1. Faria GR, Eloy C, Preto JR, et al. Primary gastric adenosquamous carcinoma in a Caucasian woman: a case report. J Med Case Rep 2010;4:351. 10.1186/1752-1947-4-351 - DOI - PMC - PubMed