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Review
. 2019 Feb 18;10(2):63-70.
doi: 10.5312/wjo.v10.i2.63.

Allergy in total knee replacement surgery: Is it a real problem?

Maristella F Saccomanno  1 , Giuseppe Sircana  1 , Giulia Masci  1 , Gianpiero Cazzato  1 , Michela Florio  1 , Luigi Capasso  1 , Marco Passiatore  1 , Giovanni Autore  1 , Giulio Maccauro  1 , Enrico Pola  2
Affiliations
Review

Allergy in total knee replacement surgery: Is it a real problem?

Maristella F Saccomanno et al. World J Orthop. .

Abstract

Total knee arthroplasty is a common procedure, with extremely good clinical results. Despite this success, it produces 20% unsatisfactory results. Among the causes of these failures is metal hypersensitivity. Metal sensitization is higher in patients with a knee arthroplasty than in the general population and is even higher in patients undergoing revision surgery. However, a clear correlation between metal sensitization and symptomatic knee after surgery has not been ascertained. Surely, patients with a clear history of metal allergy must be carefully examined through dermatological and laboratory testing before surgery. There is no globally accepted diagnostic algorithm or laboratory test to diagnose metal hypersensitivity or metal reactions. The patch test is the most common test to determine metal hypersensitivity, though presenting some limitations. Several laboratory assays have been developed, with a higher sensitivity compared to patch testing, yet their clinical availability is not widespread, due to high costs and technical complexity. Symptoms of a reaction to metal implants present across a wide spectrum, ranging from pain and cutaneous dermatitis to aseptic loosening of the arthroplasty. However, although cutaneous and systemic hypersensitivity reactions to metals have arisen, thereby increasing concern after joint arthroplasties, allergies against implant materials remain quite rare and not a well-known problem. The aim of the following paper is to provide an overview on diagnosis and management of metal hypersensitivity in patients who undergo a total knee arthroplasty in order clarify its real importance.

Keywords: Knee arthroplasty; Metal allergy; Metal hypersensitivity; Non-allergenic implants; Total knee arthroplasty.

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Conflict of interest statement

Conflict-of-interest statement: The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Preoperative diagnostic algorithm to select patients requiring hypersensitivity-friendly implants.
Figure 2
Figure 2
Algorithm for diagnosis and treatment for metal hypersensitivity-related adverse reactions.
See this image and copyright information in PMC

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