High prevalence of hypophosphatasia in Southern Israel

Evgenia Gurevich^{1

2}, Eli Hershkovitz^{2

3}, Shaked Yarza⁴, Daniel Landau^{5

6}

Affiliations

¹ Rahat Children's Health Center, Clalit Health Services, Rahat, Israel.
² Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
³ Division of Pediatrics, Soroka University Medical Center, Beer Sheva, Israel.
⁴ Clinical Research Center, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
⁵ Department of Pediatrics B, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
⁶ Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Evgenia Gurevich et al. Acta Paediatr. 2020 Apr.

. 2020 Apr;109(4):851-852.

doi: 10.1111/apa.14760. Epub 2019 Mar 10.

Evgenia Gurevich^{1

2}, Eli Hershkovitz^{2

3}, Shaked Yarza⁴, Daniel Landau^{5

6}

¹ Rahat Children's Health Center, Clalit Health Services, Rahat, Israel.
² Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
³ Division of Pediatrics, Soroka University Medical Center, Beer Sheva, Israel.
⁴ Clinical Research Center, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
⁵ Department of Pediatrics B, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
⁶ Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

No abstract available

References

1. Whyte MP, Greenberg CR, Salman NJ, Bober MB, McAlister WH, Wenkert D, et al. Enzyme-replacement therapy in life-threatening hypophosphatasia. N Engl J Med 2012; 366: 904-13.
1. Saraff V, Narayanan VK, Lawson AJ, Shaw NJ, Preece MA, Högler W. A diagnostic algorithm for children with low alkaline phosphatase activities: lessons learned from laboratory screening for hypophosphatasia. J Pediatr 2016; 172: 181-6.
1. Gurevich E, Landau D. Severe infantile hypophosphatasia. Harefuah 2017; 156: 27-8.
1. Israel's Central Bureau of Statistics: 2017 Population Census. Available at: http://www.cbs.gov.il/shnaton69/st02_19x.pdf (accessed on September 9, 2017).
1. Mornet E, Yvard A, Taillandier A, Fauvert D, Simon-Bouy B. A molecular-based estimation of the prevalence of hypophosphatasia in the European population. Ann Hum Genet 2011; 75: 439-45.