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. 2019 Mar;25(3):457-464.
doi: 10.3201/eid2503.180572.

Epidemiology of Extrapulmonary Tuberculosis among Inpatients, China, 2008-2017

Yu Pang, Jun An, Wei Shu, Fengmin Huo, Naihui Chu, Mengqiu Gao, Shibing Qin, Hairong Huang, Xiaoyou Chen, Shaofa Xu

Epidemiology of Extrapulmonary Tuberculosis among Inpatients, China, 2008-2017

Yu Pang et al. Emerg Infect Dis. 2019 Mar.

Abstract

We investigated the epidemiology of extrapulmonary tuberculosis (TB) among patients admitted to Beijing Chest Hospital, Beijing, China, during January 2008-December 2017. Of 19,279 hospitalized TB patients, 33.4% (6,433) had extrapulmonary TB and 66.6% (12,846) had pulmonary TB. The most frequent forms of extrapulmonary TB observed were skeletal TB (41.1%) and pleural TB (26.0%). Younger, female patients from rural areas were more likely to have extrapulmonary TB. However, patients with diabetes mellitus were less likely to have extrapulmonary TB compared with patients without diabetes. A higher proportion of multidrug-resistant (MDR) TB was observed among patients with extrapulmonary TB than among patients with pulmonary TB. We observed a large increase in MDR TB, from 17.3% to 35.7%, for pleural TB cases. The increasing rate of drug resistance among extrapulmonary TB cases highlights the need for drug susceptibility testing and the formulation of more effective regimens for extrapulmonary TB treatment.

Keywords: China; bacteria; drug resistance; epidemiology; extrapulmonary; inpatients; risk factor; tuberculosis; tuberculosis and other mycobacteria.

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Figures

Figure 1
Figure 1
Extrapulmonary tuberculosis disease sites among 6,433 patients in China, 2008–2017.
Figure 2
Figure 2
Trends in extrapulmonary TB and pulmonary TB, China, 2008–2017. A) Relative rates of extrapulmonary TB and pulmonary TB. B) Relative rates of different extrapulmonary TB forms. *p<0.01 compared with pulmonary TB group. Cases reported in 2-year periods. TB, tuberculosis.
See this image and copyright information in PMC

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