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Review
. 2019 Jan-Feb;170(1):e71-e76.
doi: 10.7417/CT.2019.2111.

MIG in Cutaneous Systemic Lupus Erythematosus

I Ruffilli  1
Affiliations
Free article
Review

MIG in Cutaneous Systemic Lupus Erythematosus

I Ruffilli. Clin Ter. 2019 Jan-Feb.
Free article

Abstract

Many studies reported that monokine induced by interferon (IFN)-γ(MIG), and its receptor chemokine (C-X-C motif) receptor (CXCR)3, are expressed by T cells in different types of cutaneous damages associated with lupus, and that the CXCR3-activating chemokines are produced locally, suggesting that they play a significant role in the recruitment of T cells in these inflammatory lesions. Circulating MIG levels are increased in cutaneous Systemic Lupus Erythematosus (SLE) patients and strongly correlated with the disease activity. The data discussed in this review show that there is an increasing evidence that MIG may participate in the pathogenesis of a variety of the manifestations of cutaneous SLE, even if the exact role of MIG in the pathogenesis of this disease remains to be clarified.

Keywords: Cutaneous Systemic Lupus Erythematosus; MIG.

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