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doi: 10.1016/j.neuron.2019.01.058.
Secreted APP Modulates Synaptic Activity: A Novel Target for Therapeutic Intervention?
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- PMID: 30790537
- DOI: 10.1016/j.neuron.2019.01.058
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Secreted APP Modulates Synaptic Activity: A Novel Target for Therapeutic Intervention?
Neuron.
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Abstract
The amyloid precursor protein (APP) is not only processed to the neurotoxic amyloid-β peptide but also to various types of secreted APP variants. In a recent issue of Science, Rice et al. (2019) now demonstrate that secreted APP functions as a modulator of synaptic transmission by binding to GABABR1a.
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Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission.Science. 2019 Jan 11;363(6423):eaao4827. doi: 10.1126/science.aao4827. Science. 2019. PMID: 30630900 Free PMC article.
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