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Comment
. 2019 Feb 20;101(4):557-559.
doi: 10.1016/j.neuron.2019.01.058.

Secreted APP Modulates Synaptic Activity: A Novel Target for Therapeutic Intervention?

Christian Haass  1 , Michael Willem  2
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Secreted APP Modulates Synaptic Activity: A Novel Target for Therapeutic Intervention?

Christian Haass et al. Neuron. .
Free article

Abstract

The amyloid precursor protein (APP) is not only processed to the neurotoxic amyloid-β peptide but also to various types of secreted APP variants. In a recent issue of Science, Rice et al. (2019) now demonstrate that secreted APP functions as a modulator of synaptic transmission by binding to GABABR1a.

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