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Meta-Analysis
. 2019 Mar;8(3):1054-1065.
doi: 10.1002/cam4.1998. Epub 2019 Feb 21.

Real impact of liver cirrhosis on the development of hepatocellular carcinoma in various liver diseases-meta-analytic assessment

Kazuo Tarao  1 , Akito Nozaki  2 , Takaaki Ikeda  3 , Akira Sato  4 , Hirokazu Komatsu  5 , Tatsuji Komatsu  6 , Masataka Taguri  7 , Katsuaki Tanaka  8
Affiliations
Meta-Analysis

Real impact of liver cirrhosis on the development of hepatocellular carcinoma in various liver diseases-meta-analytic assessment

Kazuo Tarao et al. Cancer Med. 2019 Mar.

Abstract

Background: It is well known that the incidence of developing hepatocelluler carcinoma (HCC) is increased in liver cirrhosis of different etiologies. However, comparison of HCC incidence in various liver diseases has not yet been estimated. We surveyed this comparison.

Methods: The PubMed database was examined (1989-2017) for studies published in English language regarding the prospective follow-up results for the development of HCC in various liver diseases. A meta-analysis was performed for each liver disease.

Results: The annual incidence (%) of HCC in the non-cirrhotic stage and cirrhotic stage, and the ratio of HCC incidence in the cirrhotic stage/non-cirrhotic stage were as follows. (a) hepatitis B virus liver disease: 0.37%→3.23% (8.73-fold), (b) hepatitis C virus liver diseases: 0.68%→4.81% (7.07-fold), (c) primary biliary cholangitis (0.26%→1.79%, 6.88-fold), (d) autoimmune hepatitis (0.19%→0.53%, 2.79-fold), and (e) NASH (0.03%→1.35%, 45.00-fold). Regarding primary hemochromatosis and alcoholic liver diseases, only follow-up studies in the cirrhotic stage were presented, 1.20% and 2.06%, respectively.

Conclusions: When the liver diseases advance to cirrhosis, the incidence of HCC is markedly increased. The development of HCC must be closely monitored by ultrasonography, magnetic resonance imaging, and computed tomography, irrespective of the different kinds of liver diseases.

Keywords: hepatocellular carcinoma; liver cirrhosis; liver diseases; meta-analysis; risk of HCC.

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Conflict of interest statement

Tanaka K has received research funding from Bristol‐Myers Squibb and Abb Vie. Nozaki A has received research funding from Gilead Sciences. Tarao K, Ikeda T, Sato A, Komatsu H, Komatsu T, and Taguri M declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Incidence of hepatocelluler carcinoma in hepatitis B virus infection
Figure 2
Figure 2
Incidence of hepatocelluler carcinoma in hepatitis C virus infection
Figure 3
Figure 3
Incidence of hepatocelluler carcinoma in primary biliary cholangitis
Figure 4
Figure 4
Incidence of hepatocelluler carcinoma in autoimmune hepatitis
Figure 5
Figure 5
Incidence of hepatocelluler carcinoma in nonalcoholic steatohepatitis
Figure 6
Figure 6
Incidence of hepatocelluler carcinoma in primary hemochromatosis
Figure 7
Figure 7
Incidence of hepatocelluler carcinoma in alcoholic liver diseases
See this image and copyright information in PMC

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