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Review
. 2019 Feb 20;20(4):925.
doi: 10.3390/ijms20040925.

Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer

Youngjin Han  1   2 , HyunA Jo  3   4 , Jae Hyun Cho  5 , Danny N Dhanasekaran  6 , Yong Sang Song  7   8   9
Affiliations
Review

Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer

Youngjin Han et al. Int J Mol Sci. .

Abstract

Tumor-suppressive effects of resveratrol have been shown in various types of cancer. However, regulation of tumor microenvironment by resveratrol is still unclear. Recent findings suggest resveratrol can potentiate its tumor-suppressive effect through modulation of the signaling pathways of cellular components (fibroblasts, macrophages and T cells). Also, studies have shown that resveratrol can suppress malignant phenotypes of cancer cells acquired in response to stresses of the tumor microenvironment, such as hypoxia, oxidative stress and inflammation. We discuss the effects of resveratrol on cancer cells in stress environment of tumors as well as interactions between cancer cells and non-cancer cells in this review.

Keywords: cancer; chemoresistance; metastasis; resveratrol; tumor microenvironment.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Tumor-suppressive effects of resveratrol targeting cancer cells in the tumor microenvironment. Various stresses in the tumor microenvironment affects cancer progression through signaling crosstalks. The effect of resveratrol on malignant phenotypes of cancer cells caused by tumor microenvironmental stress is summarized.
Figure 2
Figure 2
The effect of resveratrol on cells composing the tumor microenvironment. Cellular composition of tumor microenvironment affects cancer progression and oncogenic signaling. The effect of resveratrol on various cell types (cancer cells, CAFs, macrophages, T cells and endothelial cells) in the tumor microenvironment is displayed.
See this image and copyright information in PMC

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