Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Feb 21;19(1):42.
doi: 10.1186/s12872-019-1026-2.

The relationship between serum uric acid and lipid profile in Bangladeshi adults

Nurshad Ali  1 , Sadaqur Rahman  2 , Shiful Islam  2 , Tangigul Haque  2 , Noyan Hossain Molla  2 , Abu Hasan Sumon  2 , Rahanuma Raihanu Kathak  2 , Md Asaduzzaman  2 , Farjana Islam  2 , Nayan Chandra Mohanto  2 , Mohammad Abul Hasnat  2 , Shaikh Mirja Nurunnabi  2 , Shamim Ahmed  3
Affiliations

The relationship between serum uric acid and lipid profile in Bangladeshi adults

Nurshad Ali et al. BMC Cardiovasc Disord. .

Abstract

Background: Although the link between elevated uric acid and metabolic syndrome has been reported in some studies; the relationship of serum uric acid (SUA) with lipid profile has not well studied or little is known so far. This study was conducted to assess the relationship between SUA and lipid profile among the general adults in Bangladesh.

Methods: In total, 280 blood samples were collected from general adult participants (male, n = 150 and female, n = 130) and analyzed for serum lipid profile (TC, TG, HDL and LDL) and SUA levels. The study subjects were divided by quartiles based on SUA levels (Q1: ≤225 μmol/L, Q2: 226-285 μmol/L, Q3: 286-340 μmol/L and Q4: > 340 μmol/L). Linear regression modeling was used to evaluate the relationship between SUA and lipid levels.

Results: The prevalence of hyperuricemia was 9.2% in males and 10.4% in females. The mean level of SUA was significantly higher in male (317 ± 90 μmol/L) than in the female (255 ± 65 μmol/L) subjects (p < 0.001). An increasing trend for elevated lipid profile was observed in both gender with increasing levels of SUA in the quartiles (p < 0.05). In regression analysis, a significant positive correlation was found between SUA and TG, TC and LDL (p < 0.01) while an inverse correlation was observed between SUA and HDL (p < 0.01). After adjusting for potential confounders, lipid profile was linearly associated with SUA levels (p < 0.01 for trend).

Conclusions: Present study showed a significant positive relationship for SUA with TG, TC and LDL levels, and an inverse relationship for SUA with HDL. Early prevention of hyperuricemia and dyslipidemia may be helpful to reduce the incidence of associated cardiovascular diseases.

Keywords: Adults; Bangladesh; Cardiovascular disease; Dyslipidemia; Serum uric acid.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

This study was approved by the Internal Ethics Committee of the Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet 3114, Bangladesh. All participants were informed about the study and they gave their written consent before inclusion in the study.

Consent for publication

Not applicable.

Competing interests

The authors have no competing of interests to declare.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Association between SUA and TG (a), TC (b), HDL (c) and LDL (d). The scale in the Y-axis is not similar in all figures
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Glantzounis G, Tsimoyiannis E, Kappas A, Galaris D. Uric acid and oxidative stress. Curr Pharm Des. 2005;11:4145–4151. doi: 10.2174/138161205774913255. - DOI - PubMed
    1. Liu R, Han C, Wu D, Xia X, Gu J, Guan H, Shan Z, Teng W. Prevalence of Hyperuricemia and Gout in Mainland China from 2000 to 2014: A Systematic Review and Meta-Analysis. Biomed Res Int. 2015;2015:762820. 10.1155/2015/762820. - PMC - PubMed
    1. Remedios C, Shah M, Bhasker AG, Lakdawala M. Hyperuricemia: a reality in the Indian obese. Obes Surg. 2012;22:945–948. doi: 10.1007/s11695-012-0655-7. - DOI - PubMed
    1. Chen L, Zhu W, Chen Z, Dai H, Ren J, Chen J, et al. Relationship between hyperuricemia and metabolic syndrome. J Zhejiang Univ Sci B. 2007;8:593. doi: 10.1631/jzus.2007.B0593. - DOI - PMC - PubMed
    1. Nath SD, Voruganti VS, Arar NH, Thameem F, Lopez-Alvarenga JC, Bauer R, et al. Genome scan for determinants of serum uric acid variability. J Am Soc Nephrol. 2007;18:3156–3163. doi: 10.1681/ASN.2007040426. - DOI - PubMed

MeSH terms

LinkOut - more resources