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Meta-Analysis
. 2019 Feb 21;19(1):164.
doi: 10.1186/s12885-019-5355-4.

Blood groups A and AB are associated with increased gastric cancer risk: evidence from a large genetic study and systematic review

Yingying Mao  1   2 , Wenjun Yang  3 , Qi Qi  1 , Fei Yu  1 , Tianpei Wang  1 , Hongfei Zhang  3 , Juncheng Dai  1 , Hongxia Ma  1 , Zhibin Hu  1   4 , Hongbing Shen  1   4 , Gang Li  5 , Guangfu Jin  6   7
Affiliations
Meta-Analysis

Blood groups A and AB are associated with increased gastric cancer risk: evidence from a large genetic study and systematic review

Yingying Mao et al. BMC Cancer. .

Abstract

Background: The association of ABO blood groups with gastric cancer risk was proposed decades ago, but the results have been inconsistent.

Methods: We used two single nucleotide polymorphisms to determine ABO genotype in 4932 gastric cancer cases and 6158 controls of Chinese descent, and evaluated the associations of ABO blood groups and genotypes with risk of gastric cancer using multivariable logistic regression models. We also systematically reviewed published literature and performed a meta-analysis of all relevant studies.

Results: In the case-control study, compared with blood group O, both blood group A and AB were associated with increased gastric cancer risk (for group A, odds ratio (OR) = 1.13, 95% confidence interval (CI): 1.02-1.24; for group AB, OR = 1.18, 95% CI: 1.02-1.36, respectively). Analyses of ABO genotypes revealed associations of AO and AB with risk of gastric cancer compared with OO genotype. Consistent with the case-control study, meta-analysis of 40 studies including 33,613 cases and 2,431,327 controls demonstrated that blood group A (OR = 1.19, 95% CI: 1.13-1.25) and AB (OR = 1.09, 95% CI: 1.03-1.16) were associated with increased risk of gastric cancer.

Conclusions: Our analyses validated the association of blood group A with risk of gastric cancer, and suggested that blood group AB was also associated with gastric cancer risk. Functional investigations are warranted to elucidate the exact mechanism of ABO blood groups in gastric carcinogenesis.

Keywords: ABO blood group system; Case-control study; Gastric cancer; Meta-analysis; Systematic review.

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Conflict of interest statement

Ethics approval and consent to participate

The current study was approved by the Institutional Review Boards of Nanjing Medical University and Ningxia Medical University. Specifically, for Cohort I, written informed consent was obtained from each participant, and the study was approved by the Institutional Review Boards of all participating institutions. For Cohort II, participants were derived from the United States National Cancer Institute (NCI) GWAS, and each of the five participating studies obtained informed consent from participants and from their studies Institutional Review Board(s). The NCI Special Studies-Institutional Review Board approved the overall GWAS study. For Cohort III, the study was approved by the Institutional Review Board of Ningxia Medical University and Nanjing Medical University, and written informed consent was obtained for each participant. All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation and with the Helsinki Declaration of 1964 and later versions.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Random-effects meta-analysis forest plot of the odds ratio of gastric cancer according to blood group A with respect to group O. The studies are sorted by publication year. The solid squares are centered on the odds ratio (OR) point estimate from each study, and the horizontal line through each square indicates the 95% confidence interval (CI) for the study. The area of each square represents the magnitude of association, and the horizontal tips of the diamond represent the 95% CI
Fig. 2
Fig. 2
Fixed-effects meta-analysis forest plot of the odds ratio of gastric cancer according to blood group B with respect to group O. The studies are sorted by publication year. The solid squares are centered on the odds ratio (OR) point estimate from each study, and the horizontal line through each square indicates the 95% confidence interval (CI) for the study. The area of each square represents the magnitude of association, and the horizontal tips of the diamond represent the 95% CI
Fig. 3
Fig. 3
Fixed-effects meta-analysis forest plot of the odds ratio of gastric cancer according to blood group AB with respect to group O. The studies are sorted by publication year. The solid squares are centered on the odds ratio (OR) point estimate from each study, and the horizontal line through each square indicates the 95% confidence interval (CI) for the study. The area of each square represents the magnitude of association, and the horizontal tips of the diamond represent the 95% CI
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References

    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi: 10.3322/caac.21492. - DOI - PubMed
    1. Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ, He J. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66(2):115–132. doi: 10.3322/caac.21338. - DOI - PubMed
    1. Amieva M, Peek RM, Jr.: Pathobiology of helicobacter pylori-induced gastric Cancer. Gastroenterology 2016, 150(1):64–78. - PMC - PubMed
    1. Ladeiras-Lopes R, Pereira AK, Nogueira A, Pinheiro-Torres T, Pinto I, Santos-Pereira R, Lunet N: Smoking and gastric cancer: systematic review and meta-analysis of cohort studies. Cancer Causes Control : CCC 2008, 19(7):689–701. - PubMed
    1. Tramacere I, Negri E, Pelucchi C, Bagnardi V, Rota M, Scotti L, Islami F, Corrao G, La Vecchia C, Boffetta P. A meta-analysis on alcohol drinking and gastric cancer risk. Annals of oncology : official journal of the European Society for Med Oncol. 2012;23(1):28–36. doi: 10.1093/annonc/mdr135. - DOI - PubMed

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