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. 2019 Feb 21;20(1):63.
doi: 10.1186/s12882-019-1232-2.

Serum klotho: a potential predictor of cerebrovascular disease in hemodialysis patients

Honglan Wei  1 , Hua Li  1 , Xiaohong Song  1 , Xingguo Du  1 , Yuan Cai  1 , Chengxu Li  1 , Liping Dong  1 , Junwu Dong  2
Affiliations

Serum klotho: a potential predictor of cerebrovascular disease in hemodialysis patients

Honglan Wei et al. BMC Nephrol. .

Abstract

Background: Hemodialysis patients suffer from a serious threat of cerebrovascular disease. Klotho, as an aging-suppressor gene, contributes to protect on vascular calcification and oxidative stress, which are the risk factors of cerebrovascular disease. The purpose of the present study is to determine the relationship between serum klotho and cerebrovascular disease in patients receiving hemodialysis.

Methods: Serum klotho levels of hemodialysis patients were measured by ELISA. Cerebrovascular diseases were diagnosed by CT or MRI scans. The cognitive function of hemodialysis patients with cerebrovascular disease were evaluated with a neuropsychological battery assessing domains of global cognition verbal memory, spatial memory, executive function and verbal fluency.

Results: Eighty-eight patients were included, 57 ± 14 years, 63.64% male, 52.27% older than 60 years. Twenty-eight participants had cerebrovascular disease (23 cases had cerebral infarction, 5 cases had cerebral hemorrhage). The average level of serum klotho of all participants was 119.10 ± 47.29 pg/ml. The serum klotho level was significantly associated with cerebrovascular disease in hemodialysis patients (HR(95%CI) = 0.975(0.960-0.990), p = 0.001). The optimal cut-off value of serum klotho for predicting cerebrovascular disease in hemodialysis patients was 137.22 pg/ml, with a specificity of 96.4% and a sensitivity of 46.7%. But serum klotho was not an independent risk factor of cognitive impairment for hemodialysis patients with cerebrovascular disease (HR((95%CI) = 1.002(0.986-1.018), p = 0.776) or with cerebral infarction (HR(95%CI) = 1.005(0.987-1.023), p = 0.576).

Conclusions: The serum klotho level is a potential predictor of cerebrovascular disease in hemodialysis patients, but it is not an independent risk factor of cognitive impairment for hemodialysis patients with cerebrovascular disease.

Keywords: Cerebrovascular disease; Cognitive impairment; Hemodialysis; Klotho.

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Conflict of interest statement

Ethics approval and consent to participate

The Biological and Medical Ethics Committee of Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology (Wuhan, China) approved the study. All participants have written informed consent before the study.

Competing interests

The authors declare that they have no competing interests.

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
ROC curves for serum klotho predicting CVD
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