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Meta-Analysis
. 2019 Apr 5;39(4):BSR20182279.
doi: 10.1042/BSR20182279. Print 2019 Apr 30.

Adjuvant therapy efficacy of Chinese drugs pharmaceutics for COPD patients with respiratory failure: a meta-analysis

Chunqiu Liu  1 , Yin Li  2 , Xinqiu Wang  2 , Tong Lu  2 , Xuejing Wang  3
Affiliations
Meta-Analysis

Adjuvant therapy efficacy of Chinese drugs pharmaceutics for COPD patients with respiratory failure: a meta-analysis

Chunqiu Liu et al. Biosci Rep. .

Abstract

We performed a meta-analysis to evaluate the efficacy and safety of Western medicine combined with Tanreqing for patients with chronic obstructive pulmonary disease (COPD) and respiratory failure. We comprehensively searched several online databases from the times of their inception to November 2018. The trial quality was assessed using the bias risk tool recommended by the Cochrane library. Relative risks (RRs) and their 95% confidence intervals (CIs) for binary outcomes and weighted mean differences (MDs) with 95% CIs for continuous data were calculated. A fixed effect model indicated that integrated Tanreqing group experienced higher overall treatment effectiveness (RR = 1.23, 95% CI: 1.17-1.30, P=0.000). Pooled results from random effects models indicated the oxygen partial pressure of the test group was significantly higher than that of the control groups (MD = 9.55, 95% CI: 4.57-14.52, P<0.000). The carbon dioxide pressure of the test group was significantly lower than that of the control groups (MD = -6.06, 95% CI: -8.19 to -3.93, P=0.000). The lung function score of the test group was significantly higher than that of the control group (MD = 7.87, 95% CI: 4.45-11.29). Sensitivity analysis indicated that the data were statistically robust. Clinical effects of Western medicine combined with Tanreqing used to treat combined COPD/respiratory failure were better than those afforded by Western medicine; no serious adverse reactions were noted. However, publication bias was evident, and further trials with larger sample sizes are required.

Keywords: Chronic obstructive pulmonary disease; Meta-analysis; Respiratory failure.

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Conflict of interest statement

The authors declare that there are no competing interests associated with the manuscript.

Figures

Figure 1
Figure 1. Selection of studies for meta-analysis
Figure 2
Figure 2. Comparisons of overall effective rate between Tanreqing injections versus routine treatment
Figure 3
Figure 3. Comparisons of oxygen partial pressure between Tanreqing injections versus routine treatment
Figure 4
Figure 4. Comparisons of carbon dioxide between Tanreqing injections versus routine treatment
Figure 5
Figure 5. Comparisons of lung function between Tanreqing injections versus routine treatment
Figure 6
Figure 6. Sensitivity analysis of overall effective rate Tanreqings injection versus routine treatment
Figure 7
Figure 7. Funnel plot of publication bias
See this image and copyright information in PMC

References

    1. Mirza S. and Benzo R. (2017) Chronic obstructive pulmonary disease phenotypes: implications for care. Mayo Clin. Proc. 92, 1104–1112 10.1016/j.mayocp.2017.03.020 - DOI - PMC - PubMed
    1. Yang Y., Mao J., Ye Z., Li J., Zhao H. and Liu Y., Risk factors of chronic obstructive pulmonary disease among adults in Chinese mainland: a systematic review and meta-analysis. Respir. Med. 131, 158–165 10.1016/j.rmed.2017.08.018 - DOI - PubMed
    1. WHO (2017) Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Respir. Med. 5, 691–706 10.1016/S2213-2600(17)30293-X - DOI - PMC - PubMed
    1. Berkius J., Sundh J., Nilholm L., Fredrikson M. and Walther S.M. (2010) Long-term survival according to ventilation mode in acute respiratory failure secondary to chronic obstructive pulmonary disease: a multicenter, inception cohort study. J. Crit. Care 25, 513–539 10.1016/j.jcrc.2010.02.006 - DOI - PubMed
    1. Vargas F., Boyer A., Bui H.N., Salmi L.R., Guenard H., Gruson D.. et al. (2018) Respiratory failure in chronic obstructive pulmonary disease after extubation: value of expiratory flow limitation and airway occlusion pressure after 0.1 second (P0.1). J. Crit. Care 23, 577–584 10.1016/j.jcrc.2007.12.009 - DOI - PubMed

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