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Comment
. 2019 May;15(5):260-261.
doi: 10.1038/s41581-019-0128-5.

PIVOTAL trial: iron loading improves clinical outcomes

Daniel W Coyne  1
Affiliations
Comment

PIVOTAL trial: iron loading improves clinical outcomes

Daniel W Coyne. Nat Rev Nephrol. 2019 May.
No abstract available

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Comment on

  • Intravenous Iron in Patients Undergoing Maintenance Hemodialysis.
    Macdougall IC, White C, Anker SD, Bhandari S, Farrington K, Kalra PA, McMurray JJV, Murray H, Tomson CRV, Wheeler DC, Winearls CG, Ford I; PIVOTAL Investigators and Committees. Macdougall IC, et al. N Engl J Med. 2019 Jan 31;380(5):447-458. doi: 10.1056/NEJMoa1810742. Epub 2018 Oct 26. N Engl J Med. 2019. PMID: 30365356 Clinical Trial.

References

    1. Coyne, D. W. et al. Ferric gluconate is highly efficacious in anemic hemodialysis patients with high serum ferritin and low transferrin saturation: results of the Dialysis Patients’ Response to IV Iron with Elevated Ferritin (DRIVE) Study. J. Am. Soc. Nephrol. 18, 975–984 (2007). - DOI
    1. Kapoian, T. et al. Ferric gluconate reduces epoetin requirements in hemodialysis patients with elevated ferritin. J. Am. Soc. Nephrol. 19, 372–379 (2008). - DOI
    1. Rostoker, G., Vaziri, N. D. & Fishbane, S. Iatrogenic iron overload in dialysis patients at the beginning of the 21st century. Drugs 76, 741–757 (2016). - DOI
    1. KDOQI & National Kidney Foundation. KDOQI clinical practice guidelines and clinical practice recommendations for anemia in chronic kidney disease. Am. J. Kidney Dis. 47, S11–145 (2006). - DOI
    1. Besarab, A. et al. The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin. N. Engl. J. Med. 339, 584–590 (1998). - DOI

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