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Review
. 2019 Feb 18:4:11.
doi: 10.1038/s41541-019-0105-9. eCollection 2019.

Plague vaccine: recent progress and prospects

Wei Sun  1 , Amit K Singh  1
Affiliations
Review

Plague vaccine: recent progress and prospects

Wei Sun et al. NPJ Vaccines. .

Abstract

Three great plague pandemics, resulting in nearly 200 million deaths in human history and usage as a biowarfare agent, have made Yersinia pestis as one of the most virulent human pathogens. In late 2017, a large plague outbreak raged in Madagascar attracted extensive attention and caused regional panics. The evolution of local outbreaks into a pandemic is a concern of the Centers for Disease Control and Prevention (CDC) in plague endemic regions. Until now, no licensed plague vaccine is available. Prophylactic vaccination counteracting this disease is certainly a primary choice for its long-term prevention. In this review, we summarize the latest advances in research and development of plague vaccines.

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Conflict of interest statement

The authors declare no competing interests.

References

    1. Perry RD, Fetherston JD. Yersinia pestis—etiologic agent of plague. Clin. Microbiol. Rev. 1997;10:35–66. doi: 10.1128/CMR.10.1.35. - DOI - PMC - PubMed
    1. Stenseth, N. C. et al. Plague: past, present, and future. PLoS Med.5, e3 (2008). - PMC - PubMed
    1. Gage KL, Kosoy MY. Natural history of plague: perspectives from more than a century of research. Annu. Rev. Entomol. 2005;50:505–528. doi: 10.1146/annurev.ento.50.071803.130337. - DOI - PubMed
    1. CDC: 4 deaths, 15 cases of bubonic plague in U.S. this year. http://cbs4indy.com/2015/10/22/cdc-4-deaths-15-cases-of-bubonic-plague-i....
    1. WHO. Plague—Madagascar. http://www.who.int/csr/don/15-november-2017-plague-madagascar/en/ (2017).