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. 2019 Jan 12;6(2):ofz007.
doi: 10.1093/ofid/ofz007. eCollection 2019 Feb.

The Economic Burden and Impact on Quality of Life of Herpes Zoster and Postherpetic Neuralgia in Individuals Aged 50 Years or Older in Italy

Sean Matthews  1 , Antonio De Maria  2 , Marco Passamonti  3 , Giovanni Ristori  4 , Idalba Loiacono  5 , Anna Puggina  5 , Desmond Curran  1
Affiliations

The Economic Burden and Impact on Quality of Life of Herpes Zoster and Postherpetic Neuralgia in Individuals Aged 50 Years or Older in Italy

Sean Matthews et al. Open Forum Infect Dis. .

Abstract

Background: To estimate the health care resource utilization, costs, and impact on quality of life (QoL) of herpes zoster (HZ) and postherpetic neuralgia (PHN) in adults aged ≥50 years in Italy.

Methods: This was a prospective, observational, multicenter, community physician-based surveillance study (NCT01772160) in Italy. Health-related QoL data were collected using the EuroQoL-5 Dimension (EQ-5D) and Zoster Brief Pain Inventory (ZBPI) questionnaires. Both questionnaires were assessed at days 0 (HZ rash onset), 15, 30, 60, and 90 for all patients, and monthly thereafter for patients who developed PHN. Resource utilization was recorded for 3 months post-HZ onset and 9 months for PHN patients. Costs from both payer and societal perspectives were estimated and were composed of direct medical costs (general practitioner/specialist visits, procedures, hospitalizations, medications), work loss by patient/caregiver, and transport costs.

Results: A total of 391 patients with HZ were included, of whom 40 developed PHN. The mean ZBPI worst pain score was 5.7 at day 0, reducing to 2.6 at day 30 and 0.7 by day 90. Patients with PHN had a mean worst pain score of 5.7 at day 90. We estimated an overall disutility associated with HZ of 0.134. The mean cost per HZ patient from a payer/societal perspective was €153/€298, respectively, and the mean cost per HZ patients who developed PHN was €176/€426, respectively.

Conclusions: HZ is associated with impaired QoL and substantial health care resource use, highlighting the need for preventive strategies. This could reduce the disease burden for the patient and health care system.

Clinicaltrialsgov study registry: NCT01772160.

Keywords: QALY; economic burden; herpes zoster (HZ); postherpetic neuralgia (PHN); quality of life (QoL).

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Figures

Figure 1.
Figure 1.
Mean Zoster Brief Pain Inventory worst pain scores by age category and time. Abbreviations: YOA, years of age; ZBPI, Zoster Brief Pain Inventory.
Figure 2.
Figure 2.
Mean costs by payer perspective and complication category. Abbreviations: HZ, herpes zoster; PHN, postherpetic neuralgia.
Figure 3.
Figure 3.
Focus on the patient.
See this image and copyright information in PMC

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References

    1. Bowsher D. The lifetime occurrence of herpes zoster and prevalence of post-herpetic neuralgia: a retrospective survey in an elderly population. Eur J Pain 1999; 3:335–42. - PubMed
    1. Brisson M, Edmunds WJ, Law B, et al. . Epidemiology of varicella zoster virus infection in Canada and the United Kingdom. Epidemiol Infect 2001; 127:305–14. - PMC - PubMed
    1. Edmunds WJ, Brisson M, Rose JD. The epidemiology of herpes zoster and potential cost-effectiveness of vaccination in England and Wales. Vaccine 2001; 19:3076–90. - PubMed
    1. Cohen JI. Herpes zoster. N Engl J Med 2013; 369:1766–7. - PMC - PubMed
    1. Bricout H, Perinetti E, Marchettini P, et al. . Burden of herpes zoster-associated chronic pain in Italian patients aged 50 years and over (2009-2010): a GP-based prospective cohort study. BMC Infect Dis 2014; 14:1–11. - PMC - PubMed

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