Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 May;15(5):917-918.
doi: 10.1080/15548627.2019.1580513. Epub 2019 Feb 22.

The emerging role of human TBK1 in virus-induced autophagy

Ahmad Liyana  1   2 , Sancho-Shimizu Vanessa  1   3
Affiliations
Comment

The emerging role of human TBK1 in virus-induced autophagy

Ahmad Liyana et al. Autophagy. 2019 May.

Abstract

Recent studies have suggested a role for TBK1 in mediating inflammation through macroautophagy/autophagy. While its function in inducing interferon production in response to viral infection has been extensively studied, its role in antiviral autophagy is only beginning to be appreciated. Herein we discuss the role of this multifunctional protein in both antiviral IFN production and in cytoprotective autophagy during HSV-1 infection. Lastly, we highlight the potential implication of TBK1 in the management of inflammation through autophagy, particularly within the central nervous system.

Keywords: Autophagy; CNS; HSV-1; TBK1; infection; inflammation; interferon.

PubMed Disclaimer

Comment on

References

    1. Ahmad L, Mashbat B, Leung C, et al. Human TANK-binding kinase 1 is required for early autophagy induction upon herpes simplex virus 1 infection. J Allergy Clin Immunol. 2019 Feb;143(2):765–769.e7. doi: 10.1016/j.jaci.2018.09.013. Epub 2018 Oct 5–. - DOI - PubMed

Publication types

Substances