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. 2019 Jun;8(3):385-386.
doi: 10.1089/jayao.2018.0141. Epub 2019 Feb 22.

Short-Term Changes in Cardiac Function in Osteosarcoma Patients Receiving Anthracyclines

Susan C Gilchrist  1   2 , Michael Roth  3 , J Andrew Livingston  3   4 , Michelle A T Hildebrandt  5 , Eugenie S Kleinerman  3   6 , Jose Banchs  2
Affiliations

Short-Term Changes in Cardiac Function in Osteosarcoma Patients Receiving Anthracyclines

Susan C Gilchrist et al. J Adolesc Young Adult Oncol. 2019 Jun.

Abstract

Studies of cardiac function in adolescent and young adult survivors have been performed at least a decade after anthracycline exposure, with little knowledge of short-term changes in cardiac function in this age group. To this end, we evaluated cardiac function within a 2-year period among 18 patients who received high-dose anthracyclines for osteosarcoma treatment. At 2 years, there was a significant decline in left ventricular ejection fraction (p = 0.005), with 8 of 18 patients having a >10% reduction. There was a significant change in E-wave velocity (p = 0.04). To our knowledge, this is the first study assessing short-term change in systolic and diastolic function in osteosarcoma patients receiving anthracyclines.

Keywords: adolescent and young adult cancer survivors; anthracyclines; cardiac function; osteosarcoma.

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Conflict of interest statement

No competing financial interests exist.

Figures

<b>FIG. 1.</b>
FIG. 1.
Two-year change in left ventricular ejection fraction (A) and E-wave velocity (B) in osteosarcoma patients receiving anthracyclines with dexrazoxane (gray) and without dexrazoxane (white). LVEF, left ventricular ejection fraction.
See this image and copyright information in PMC

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