Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Mar;9(1):1.
doi: 10.1051/bmdcn/2019090101. Epub 2019 Feb 22.

A brief literature review and own clinical experience in prophylaxis of oral mucositis in children using low level laser therapy

Sergey Moskvin  1 , Denis Pritiko  2 , Elena Sergeenko  2 , Elena Lukash  2 , Leonid Gusev  2
Affiliations

A brief literature review and own clinical experience in prophylaxis of oral mucositis in children using low level laser therapy

Sergey Moskvin et al. Biomedicine (Taipei). 2019 Mar.

Abstract

Objective: The article describes the experience of clinical application of low level laser therapy in pediatric oncology for the prevention and treatment of chemotherapy complications such as oral mucositis.

Background: For this purpose, for the first time in the world non-invasive laser blood illumination is used on the sinocarotid zone (on the projection of the common carotid artery symmetrically) and popliteal fossa in order to stimulate the phagocytic activity of leukocytes.

Methods: 25 children with different oncological diseases were given non-invasive laser blood illumination treatment (904 nm, pulse mode, 100 ns, 50-150 Hz, 5-7 W, 4 cm2, 1-2 minutes daily per each procedure) 1-3 days before the beginning of chemotherapy. For the objectification of the results of treatment, the phagocytic activity of leukocytes was evaluated.

Results: None of the children who underwent low level laser therapy course had any complications and no cases of oral mucositis developed.

Conclusions: Clinical experience has shown high efficacy and safety of low level laser therapy aimed at preventing the development of complications of chemotherapy, primarily oral mucositis, and stimulating the phagocytic activity of leukocytes.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Impact localization.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Al-Dasooqi N, Sonis ST, Bowen JM, Bateman E, Blijlevens N, Gibson RJ, et al. Emerging evidence on the pathobiology of mucositis. Support Care Cancer. 2013; 21(11): 3233–41. 10.1007/s00520-013-1900-x - DOI - PubMed
    1. Ethier MC, Regier DA, Tomlinson D, Judd P, Doyle J, Gassas A, et al. Perspectives toward oral mucositis prevention from parents and health care professionals in pediatric cancer. Support Care Cancer. 2012; 20(8): 1771–7. 10.1007/s00520-011-1274-x - DOI - PubMed
    1. Guyatt G, Andrews J, Kunz R, Falck-Ytter Y, Vist G, Liberati A, et al. GRADE: going from evidence to recommendations. BMJ. 2008; 336(7652): 1049–51. 10.1136/bmj.39493.646875.AE - DOI - PMC - PubMed
    1. Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008(1); 336(7650): 924–6. 10.1136/bmj.39489.470347.AD - DOI - PMC - PubMed
    1. Keefe DM. Intestinal mucositis: mechanisms and management. Curr Opin Oncol. 2007; 19(4): 323–7. 10.1097/CCO.0b013e3281214412 - DOI - PubMed

LinkOut - more resources