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Clinical Trial
. 2019 Feb 22;14(2):e0212264.
doi: 10.1371/journal.pone.0212264. eCollection 2019.

Sub-national TB prevalence surveys in India, 2006-2012: Results of uniformly conducted data analysis

V K Chadha  1   2 , Sharda M Anjinappa  1 , Paresh Dave  3 , Kiran Rade  4   5 , D Baskaran  6 , P Narang  7 , C Kolappan  6 , K Katoch  8 , S K Sharma  9 , V G Rao  10 , A N Aggarwal  11 , P Praseeja  1 , R Jitendra  1 , S Swaminathan  6   12   13
Affiliations
Clinical Trial

Sub-national TB prevalence surveys in India, 2006-2012: Results of uniformly conducted data analysis

V K Chadha et al. PLoS One. .

Abstract

Setting: Community based tuberculosis (TB) prevalence surveys in ten sites across India during 2006-2012.

Objective: To re-analyze data of recent sub-national surveys using uniform statistical methods and obtain a pooled national level estimate of prevalence of TB.

Methods: Individuals ≥15 years old were screened by interview for symptoms suggestive of Pulmonary TB (PTB) and history of anti-TB treatment; additional screening by chest radiography was undertaken in five sites. Two sputum specimens were examined by smear and culture among Screen-positives. Prevalence in each site was estimated after imputing missing values to correct for bias introduced by incompleteness of data. In five sites, prevalence was corrected for non-screening by radiography. Pooled prevalence of bacteriologically positive PTB was estimated using Random Effects Model after excluding data from one site. Overall prevalence of TB (all ages, all types) was estimated by adjusting for extra-pulmonary TB and Pediatric TB.

Results: Of 769290 individuals registered, 715989 were screened by interview and 294532 also by radiography. Sputum specimen were examined from 50 852 individuals. Estimated prevalence of smear positive, culture positive and bacteriologically positive PTB varied between 108.4-428.1, 147.9-429.8 and 170.8-528.4 per 100000 populations in different sites. Pooled estimate of prevalence of bacteriologically positive PTB was 350.0 (260.7, 439.0). Overall prevalence of TB was estimated at 300.7 (223.7-377.5) in 2009, the mid-year of surveys. Prevalence was significantly higher in rural compared to urban areas.

Conclusion: TB burden continues to be high in India suggesting further strengthening of TB control activities.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flowchart depicting numbers of individuals registered, numbers screened by interview and/or Chest X-ray, numbers eligible for sputum examination, numbers actually examined and the numbers of bacteriologically confirmed pulmonary TB cases detected by site.
Fig 2
Fig 2. Estimated prevalence of bacteriologically positive pulmonary TB by site and the pooled prevalence.
See this image and copyright information in PMC

References

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