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Review
. 2019 May;98(5):1051-1069.
doi: 10.1007/s00277-019-03622-0. Epub 2019 Feb 22.

Management of sepsis in neutropenic cancer patients: 2018 guidelines from the Infectious Diseases Working Party (AGIHO) and Intensive Care Working Party (iCHOP) of the German Society of Hematology and Medical Oncology (DGHO)

Matthias Kochanek  1   2 , E Schalk  3   4 , M von Bergwelt-Baildon  3   5 , G Beutel  3   6 , D Buchheidt  3   7 , M Hentrich  8 , L Henze  3   9 , M Kiehl  3   10 , T Liebregts  3   11 , M von Lilienfeld-Toal  12 , A Classen  13 , S Mellinghoff  13 , O Penack  14 , C Piepel  15 , B Böll  13   3
Affiliations
Review

Management of sepsis in neutropenic cancer patients: 2018 guidelines from the Infectious Diseases Working Party (AGIHO) and Intensive Care Working Party (iCHOP) of the German Society of Hematology and Medical Oncology (DGHO)

Matthias Kochanek et al. Ann Hematol. 2019 May.

Abstract

Sepsis and septic shock are major causes of mortality during chemotherapy-induced neutropenia for malignancies requiring urgent treatment. Thus, awareness of the presenting characteristics and prompt management is most important. Improved management of sepsis during neutropenia may reduce the mortality of cancer therapies. However, optimal management may differ between neutropenic and non-neutropenic patients. The aim of the current guideline is to give evidence-based recommendations for hematologists, oncologists, and intensive care physicians on how to manage adult patients with neutropenia and sepsis.

Keywords: Cancer; Guideline; Management; Neutropenia; Sepsis; Septic shock.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Sepsis definition for neutropenic patients analog to Sepsis-3 guidelines [12]. (ANC, absolute neutrophil count; FUO, fever of unknown origin; qSOFA, quick SOFA; SOFA, Sepsis-Related Organ Failure Assessment; GCS, Glasgow Coma Scale; SBP, systolic blood pressure; MAP, mean arterial pressure)
Fig. 2
Fig. 2
Diagram for diagnosis of sepsis and septic shock. Important clinical symptoms are highlighted in bold. ANC, absolute neutrophil count; SBP, systolic blood pressure; MAP, mean arterial pressure; bpm, beats per minute; SD, standard deviation; CRP, C-reactive protein; PCT, procalcitonin
See this image and copyright information in PMC

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