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Case Reports
. 1986 Feb;38(2):141-9.
doi: 10.1016/0090-1229(86)90133-9.

Use of an IgA-depleted intravenous immunoglobulin in a patient with an anti-IgA antibody

C Cunningham-Rundles, S Wong, J Björkander, L A Hanson
Case Reports

Use of an IgA-depleted intravenous immunoglobulin in a patient with an anti-IgA antibody

C Cunningham-Rundles et al. Clin Immunol Immunopathol. 1986 Feb.

Abstract

In this report we describe the use of an IgA-depleted preparation of intravenous gamma-globulin in a patient with hypogammaglobulinemia and an anti-IgA antibody. An IgA containing intravenous gamma-globulin had previously produced anaphylactoid reactions, immune complex formation, and complement activation. The patient has had no reactions to the IgA-depleted preparation after 18 months of treatment; immune complex formation and complement activation have not been demonstrated, and the titer of antibody to IgA has diminished.

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