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. 2019 Jun;80(6):1682-1690.
doi: 10.1016/j.jaad.2019.02.038. Epub 2019 Feb 21.

Inflammatory dietary pattern and incident psoriasis, psoriatic arthritis, and atopic dermatitis in women: A cohort study

Alanna C Bridgman  1 , Abrar A Qureshi  2 , Tricia Li  3 , Fred K Tabung  4 , Eunyoung Cho  5 , Aaron M Drucker  6
Affiliations

Inflammatory dietary pattern and incident psoriasis, psoriatic arthritis, and atopic dermatitis in women: A cohort study

Alanna C Bridgman et al. J Am Acad Dermatol. 2019 Jun.

Abstract

Background: Diet is a modulator of inflammation that might impact inflammatory skin diseases.

Objective: To assess the relationship between pro-inflammatory dietary patterns and incident psoriasis, psoriatic arthritis (PsA), and atopic dermatitis (AD).

Methods: We conducted cohort studies among women in the Nurses' Health Study II. The Empirical Dietary Inflammatory Pattern (EDIP) score was calculated at baseline and every 4 years. Incident psoriasis, PsA, and AD were assessed by validated self-report. We used multivariable-adjusted Cox proportional hazards models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between EDIP quintiles and risk for psoriasis, PsA, and AD.

Results: We had 85,185 participants in the psoriasis analysis and 63,443 in the AD analysis. There were 1432 cases of psoriasis, 262 cases of PsA, and 403 cases of AD. Pro-inflammatory dietary patterns were not associated with the risk for outcomes in multivariable models (all P values for trend >.05). HRs comparing the highest to the lowest EDIP quintile were 0.99 (95% CI 0.83-1.18) for psoriasis, 1.22 (95% CI 0.81-1.83) for PsA, and 0.96 (95% CI 0.69-1.34) for AD.

Limitations: Recall and self-report.

Conclusion: Our findings do not support dietary inflammatory potential as a risk factor for psoriasis, PsA, or AD.

Keywords: CRP; EDIP; IL-6; Nurses' Health Study II; TNF-α; atopic dermatitis; inflammatory diet; psoriasis; psoriatic arthritis.

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Conflict of interest statement

Conflicts of interest: In the last three years, Dr. Drucker served as an investigator and has received research funding from Sanofi and Regeneron and has been a consultant for Sanofi, RTI Health Solutions, Eczema Society of Canada and Canadian Agency for Drugs and Technology in Health. He has received honoraria from Prime Inc, Spire Learning, CME Outfitters and Eczema Society of Canada. His institution receives education grants from Sanofi. Dr. Qureshi has served as a consultant (honoraria donated to charity) for Eli Lilly, Amgen, Centers for Disease Control, Janssen, Merck, Novartis and Pfizer, has been an investigator (non-compensation) for Sanofi and has a patent pending for Nix-Tix tick remover.

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