Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Jan 17;231(4735):252-5.
doi: 10.1126/science.3079918.

Human T-cell gamma chain genes: organization, diversity, and rearrangement

T Quertermous, C Murre, D Dialynas, A D Duby, J L Strominger, T A Waldman, J G Seidman

Human T-cell gamma chain genes: organization, diversity, and rearrangement

T Quertermous et al. Science. .

Abstract

The human T-cell gamma chain genes have been characterized in an attempt to better understand their role in immune response. These immunoglobulin-like genes are encoded in the genome in variable, joining, and constant segments. The human gamma genes include at least six variable region genes, two joining segments, and two constant-region genes in germline DNA. Variable and joining segments recombine during the development of T cells to form rearranged genes. The diversity of human gamma genes produced by this recombinational mechanism is greater than that produced by the murine genome but is more limited than that of other immunoglobulin-like genes.

PubMed Disclaimer

Publication types

LinkOut - more resources