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. 2019 Apr:32:28-34.e1.
doi: 10.1016/j.annepidem.2019.01.012. Epub 2019 Feb 5.

Association of secondhand tobacco smoke exposure during childhood on adult cardiovascular disease risk among never-smokers

Maxwell Pistilli  1 , Virginia J Howard  2 , Monika M Safford  3 , Brian K Lee  1 , Gina S Lovasi  1 , Mary Cushman  4 , Angela M Malek  5 , Leslie A McClure  6 ; REGARDS Investigators
Affiliations

Association of secondhand tobacco smoke exposure during childhood on adult cardiovascular disease risk among never-smokers

Maxwell Pistilli et al. Ann Epidemiol. 2019 Apr.

Abstract

Purpose: Adult secondhand tobacco smoke (SHS) exposure is related to stroke and coronary heart disease (CHD) risk, but long-term effects are less clear. We evaluated whether childhood SHS exposure affects subsequent stroke or CHD risk among adult black and white never-smokers followed for stroke and CHD.

Methods: In this prospective cohort study, inverse probability weights were calculated to correct for bias due to attrition and survey nonresponse. Cox proportional hazards models were used to assess hazard ratios and 95% confidence intervals for stroke or CHD, separately, by number of childhood household smokers.

Results: Of 13,142 eligible participants, 6136 had childhood SHS exposure assessed. Baseline mean (SD) age was 63.5 (9.0), 65% were female, 30% black, 46% reported 0 childhood household smokers, 36% reported 1, and 18% reported 2+. In 60,649 person-years, 174 strokes were observed (2.9% of participants), and in 45,195 person-years, 114 CHD events were observed (2.1% of participants). The weighted and adjusted hazard ratios (95% confidence intervals) of stroke for 2+ versus 0 childhood household smokers was 1.66 (1.29-2.13) and was 1.15 (0.82-1.59) for CHD.

Conclusions: We observed a significant association between childhood SHS exposure and stroke, but not CHD, after age 45 years and adjusting for missing information.

Keywords: Coronary disease; Environmental exposure; Stroke; Tobacco smoke pollution.

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Conflict of interest statement

Conflict of Interest and Authorship Conformation Form

Please check the following as appropriate:

  1. All authors have participated in (a) conception and design, or analysis and interpretation of the data; (b) drafting the article or revising it critically for important intellectual content; and (c) approval of the final version.

  2. This manuscript has not been submitted to, nor is under review at, another journal or other publishing venue.

  3. The authors have no affiliation with any organization with a direct or indirect financial interest in the subject matter discussed in the manuscript

  4. The following authors have affiliations with organizations with direct or indirect financial interest in the subject matter discussed in the manuscript:

[Table: see text]

Figures

Figure 1:
Figure 1:
Flowchart describing the study participants. There are 6,136 unique participants in the stroke and CHD analyses combined. CHD=coronary heart disease
See this image and copyright information in PMC

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