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. 2018;43(4):434-441.
doi: 10.5114/ceji.2018.81353. Epub 2018 Dec 31.

Complete blood count-derived inflammatory markers in adolescents with primary arterial hypertension: a preliminary report

Piotr Skrzypczyk  1 , Joanna Przychodzień  1 , Marta Bombińska  2 , Zuzanna Kaczmarska  2 , Magdalena Mazur  2 , Małgorzata Pańczyk-Tomaszewska  1
Affiliations

Complete blood count-derived inflammatory markers in adolescents with primary arterial hypertension: a preliminary report

Piotr Skrzypczyk et al. Cent Eur J Immunol. 2018.

Abstract

Aim of the study: The aim of our study was to evaluate selected inflammatory markers in children with untreated primary hypertension and to establish the relation between inflammatory markers and 24-hour ambulatory blood pressure monitoring (ABPM) and clinical and biochemical parameters.

Material and methods: In 54 children (15.12 ±2.02 years) with untreated primary hypertension, with excluded overt inflammation, we evaluated: neutrophils (NEU; 1000/μl), lymphocytes (LYM; 1000/μl), platelets (PLT; 1000/μl), mean platelet volume (MPV; fl), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), ABPM (OSCAR 2 SUNTECH), and selected clinical and biochemical parameters. The control group consisted of 20 healthy children (15.55 ±2.27 years).

Results: Children with primary hypertension had (p < 0.01) higher 24-hour systolic, diastolic and mean blood pressure, systolic and diastolic blood pressure loads, and pulse pressure. Hypertensive children did not differ in inflammatory indicators (NEU, LYM, PLT, MPV, NLR, PLR) from the control group. In 54 hypertensive children we found the following correlations: between office systolic and diastolic blood pressure and MPV (r = 0.35, p = 0.011, r = 0.36, p = 0.008), between 24-hour ambulatory mean arterial pressure Z-score and NLR (r = 0.30, p = 0.030), 24-hour systolic blood pressure load and NLR (r = 0.38, p = 0.005), plasma renin activity and neutrophil count, NLR, PLR (r = 0.47, p = 0.016, r = 0.64, p < 0.001, r = 0.42, p = 0.033), urinary albumin loss and neutrophil count, NLR (r = 0.46, p = 0.001 and r = 0.42, p = 0.003). Multivariate analysis revealed that office SBP Z-score was related to MPV (β = 0.35, p = 0.008) and albuminuria to neutrophil count (β = 0.62, p = 0.018).

Conclusions: In children with primary arterial hypertension there may be a relation between blood pressure, urinary albumin loss, and subclinical inflammation.

Keywords: adolescents; complete blood count; inflammation; primary hypertension.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Correlations between mean platelet volume and office blood pressure in adolescents with primary hypertension
Fig. 2
Fig. 2
Correlations between neutrophil-to-lymphocyte ratio and ambulatory blood pressure in adolescents with primary hypertension
Fig. 3
Fig. 3
Correlations between neutrophil count, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and plasma renin activity in adolescents with primary hypertension
Fig. 4
Fig. 4
Correlations between neutrophil count, neutrophil-to-lymphocyte ratio and urinary albumin loss in adolescents with primary hypertension
See this image and copyright information in PMC

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