Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Feb 4:8:F1000 Faculty Rev-149.
doi: 10.12688/f1000research.16654.1. eCollection 2019.

Vasopressin-aquaporin-2 pathway: recent advances in understanding water balance disorders

Marianna Ranieri  1 , Annarita Di Mise  1 , Grazia Tamma  1   2 , Giovanna Valenti  1   2   3
Affiliations
Review

Vasopressin-aquaporin-2 pathway: recent advances in understanding water balance disorders

Marianna Ranieri et al. F1000Res. .

Abstract

The alteration of water balance and related disorders has emerged as being strictly linked to the state of activation of the vasopressin-aquaporin-2 (vasopressin-AQP2) pathway. The lack of responsiveness of the kidney to the vasopressin action impairs its ability to concentrate the urine, resulting in polyuria, polydipsia, and risk of severe dehydration for patients. Conversely, non-osmotic release of vasopressin is associated with an increase in water permeability in the renal collecting duct, producing water retention and increasing the circulatory blood volume. This review highlights some of the new insights and recent advances in therapeutic intervention targeting the dysfunctions in the vasopressin-AQP2 pathway causing diseases characterized by water balance disorders such as congenital nephrogenic diabetes insipidus, syndrome of inappropriate antidiuretic hormone secretion, nephrogenic syndrome of inappropriate antidiuresis, and autosomal dominant polycystic kidney disease. The recent clinical data suggest that targeting the vasopressin-AQP2 axis can provide therapeutic benefits in patients with water balance disorders.

Keywords: ADPKD; AQP2; NDI; NSIAD; SIADH; Vasopressin.

PubMed Disclaimer

Conflict of interest statement

No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.

Figures

Figure 1.
Figure 1.. Targeting the vasopressin–AQP2 pathway in water balance disorders.
Alterations of the vasopressin–AQP2 axis, causes of the disease, and principal effects observed in selected water balance disorders. AQP2, aquaporin-2; CNS, central nervous system; V2R, type 2 vasopressin receptor.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Knepper MA, Kwon TH, Nielsen S: Molecular physiology of water balance. N Engl J Med. 2015;372(14):1349–58. 10.1056/NEJMra1404726 - DOI - PMC - PubMed
    1. Jung HJ, Kwon TH: Molecular mechanisms regulating aquaporin-2 in kidney collecting duct. Am J Physiol Renal Physiol. 2016;311(6):F1318–F1328. 10.1152/ajprenal.00485.2016 - DOI - PMC - PubMed

    2. F1000 Recommendation

    1. Lee JW, Chou CL, Knepper MA: Deep Sequencing in Microdissected Renal Tubules Identifies Nephron Segment-Specific Transcriptomes. J Am Soc Nephrol. 2015;26(11):2669–77. 10.1681/ASN.2014111067 - DOI - PMC - PubMed
    1. Nedvetsky PI, Tamma G, Beulshausen S, et al. : Regulation of aquaporin-2 trafficking. Handb Exp Pharmacol. 2009; (190):133–57. 10.1007/978-3-540-79885-9_6 - DOI - PubMed
    1. Rojek A, Füchtbauer EM, Kwon TH, et al. : Severe urinary concentrating defect in renal collecting duct-selective AQP2 conditional-knockout mice. Proc Natl Acad Sci U S A. 2006;103(15):6037–42. 10.1073/pnas.0511324103 - DOI - PMC - PubMed

    2. F1000 Recommendation

Publication types

MeSH terms