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Case Reports
. 2019 Feb 8:7:2050313X19828918.
doi: 10.1177/2050313X19828918. eCollection 2019.

Gastric mixed adenoneuroendocrine carcinoma case report

Miguel Angel Moyón Constante  1 , Fernando Xavier Moyón Constante  1 , Jorge Fernando Tufiño  1 , Andres Cárdenas Patiño  1 , Gabriel Alejandro Molina  2 , Bernardo Miguel Gutierrez  3
Affiliations
Case Reports

Gastric mixed adenoneuroendocrine carcinoma case report

Miguel Angel Moyón Constante et al. SAGE Open Med Case Rep. .

Abstract

Mixed adenoneuroendocrine carcinomas are rare tumors that contain both an exocrine and an endocrine component. Since the latest classification by the World Health Organization and with the aid of immunostaining, more mixed adenoneuroendocrine carcinomas are now identified and diagnosed. Nonetheless, our knowledge of these tumors is still limited, notably concerning gastric variants, as the cases reported in the literature are very limited. The clinical and surgical treatment, including the chemotherapy schemes, the prognosis, and recurrence still represent challenges for the medical teams. We present the case of a 62-year-old woman. After an upper endoscopy revealed multiple polyps and a low-grade neuroendocrine tumor, a D2 radical gastrectomy was performed. A low output esophageal anastomotic leak was discovered in the postoperative period and successfully managed. Pathology revealed a gastric mixed adenoneuroendocrine carcinoma, the first case of this kind reported in Ecuador. Patient is doing well and under constant surveillance up until her 13th postoperative month.

Keywords: Gastric cancer; mixed adenoneuroendocrine carcinoma.

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Conflict of interest statement

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Gastric mucosa with MANEC, atypia in gland cells, and dysplasia in enterochromaffin cells.
Figure 2.
Figure 2.
Positive immunostaining for CD56.
Figure 3.
Figure 3.
Positive immunostaining for cytokeratin 20.
Figure 4.
Figure 4.
Positive immunostaining for chromogranin 20, within tumor.
Figure 5.
Figure 5.
Esophagogram which did not show any leakage or stenosis.
Figure 6.
Figure 6.
Patient with good clinical condition and fistula.
Figure 7.
Figure 7.
Metal stent covering the fistula.
See this image and copyright information in PMC

References

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