Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Apr;119(5):564-582.
doi: 10.1002/jso.25421. Epub 2019 Feb 25.

Systemic treatment for metastatic colorectal cancer in the era of precision medicine

Jaideep Sandhu  1 , Viraj Lavingia  2 , Marwan Fakih  3
Affiliations
Review

Systemic treatment for metastatic colorectal cancer in the era of precision medicine

Jaideep Sandhu et al. J Surg Oncol. 2019 Apr.

Abstract

The treatment of metastatic colorectal cancer has evolved over the last two decades with the FDA approval of several cytotoxic, biological, and targeted agents. In this paper, we review the impact of sidedness, RAS, BRAF, HER-2, and other immune biomarkers on metastatic colorectal cancer treatment selection and sequencing in both the palliative and curative intent settings.

Keywords: biomarkers; chemotherapy; colorectal cancer; immunotherapy; targeted therapy.

PubMed Disclaimer

MeSH terms