Fail-Fast in Respiratory Syncytial Virus Vaccine Development
- PMID: 30802410
- PMCID: PMC6701037
- DOI: 10.1164/rccm.201901-0233ED
Fail-Fast in Respiratory Syncytial Virus Vaccine Development
Comment on
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Local and Systemic Immunity against Respiratory Syncytial Virus Induced by a Novel Intranasal Vaccine. A Randomized, Double-Blind, Placebo-controlled Clinical Trial.Am J Respir Crit Care Med. 2019 Aug 15;200(4):481-492. doi: 10.1164/rccm.201810-1921OC. Am J Respir Crit Care Med. 2019. PMID: 30753101 Free PMC article. Clinical Trial.
References
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- Mazur NI, Higgins D, Nunes MC, Melero JA, Langedijk AC, Horsley N, et al. Respiratory Syncytial Virus Network (ReSViNET) Foundation. The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates. Lancet Infect Dis. 2018;18:e295–e311. - PubMed
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- Novavax announces topline RSV F vaccine data from two clinical trials in older adults 5. Gaithersburg, MD: Novavax; 2016 [accessed 2019 Jan 28]. Available from: http://ir.novavax.com/news-releases/news-release-details/novavax-announc....
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- Novavax reaches significant enrollment milestone in the prepare(TM) phase 3 trial of its RSV F vaccine. Gaithersburg, MD: Novavax; 2018 [accessed 2019 Jan 28]. Available from: http://ir.novavax.com/news-releases/news-release-details/novavax-reaches....
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- Khanna R, Guler I, Nerkar A. Fail often, fail big, and fail fast? Learning from small failures and R&D performance in the pharmaceutical Industry. Acad Manag J. 2015;59:436–459.
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- Ascough S, Vlachantoni I, Kalyan M, Haijema B-J, Wallin-Weber S, Dijkstra-Tiekstra M, et al. Local and systemic immunity against respiratory syncytial virus induced by a novel intranasal vaccine: a randomized, double-blind, placebo-controlled clinical trial. Am J Respir Crit Care Med. 2019;200:481–492. - PMC - PubMed
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