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. 2019 Jan-Dec:18:2325958219831045.
doi: 10.1177/2325958219831045.

HIV Infection-Associated Frailty: The Solution for Now Is Antiretroviral Drugs: A Perspective

Stephen A Klotz  1 , Nicole Bradley  2 , Shannon Smith  1 , Nafees Ahmad  2
Affiliations

HIV Infection-Associated Frailty: The Solution for Now Is Antiretroviral Drugs: A Perspective

Stephen A Klotz et al. J Int Assoc Provid AIDS Care. 2019 Jan-Dec.

Abstract

This Perspective article provides a new view of frailty as it relates to HIV-1 infection. We discuss new findings and where our research is going.

Keywords: CD4 count and CD8 T cells; HIV-1 infection; antiretroviral drugs; frailty; immune function recovery.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
HIV-positive patients (HIV+) on continuous ART with undetectable viral loads followed over 3 years (n = 110) compared to age-matched uninfected controls (HIV−; n = 75). A, The line in the box shows mean values of total lymphocytes for controls, patients on ART <10 years and >10 years, respectively. B, CD8 cells decline as CD4 count increase in number. C, CD8 cells expressing CD28 as CD4 count numbers increase. D, Late stage, terminally differentiated CD8 cells (expressing CD28−CD57+) in comparison to CD4 count numbers. ART indicates antiretroviral therapy.
See this image and copyright information in PMC

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