. 2019 Jan 15:76:6-9.

doi: 10.1016/j.placenta.2018.12.007. Epub 2018 Dec 21.

Decreased placental glypican expression is associated with human fetal growth restriction

T Gunatillake¹, A Chui², E Fitzpatrick³, V Ignjatovic⁴, P Monagle⁵, J Whitelock⁶, D Zanten⁷, J Eijsink⁷, A Borg⁸, J Stevenson⁸, S P Brennecke⁸, J J H M Erwich⁷, J M Said⁹, P Murthi¹⁰

Affiliations

¹ Department of Obstetrics and Gynaecology, The University of Melbourne, Sunshine Hospital, St Albans, 3021, Australia. Electronic address: gunatillake.t@unimelb.edu.au.
² Department of Obstetrics and Gynaecology, The University of Melbourne, Sunshine Hospital, St Albans, 3021, Australia.
³ Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, 3052, Australia.
⁴ Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, 3052, Australia; Department of Clinical Haematology, Royal Children's Hospital, Parkville, 3052, Australia.
⁵ Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, 3052, Australia; Department of Paediatrics, The University of Melbourne, Royal Children's Hospital, Parkville, 3052, Australia; Department of Clinical Haematology, Royal Children's Hospital, Parkville, 3052, Australia.
⁶ Graduate School of Biomedical Engineering, University of New South Wales, Kensington, Australia.
⁷ Department of Obstetrics and Gynaecology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.
⁸ Department of Maternal-Fetal Medicine Pregnancy Research Centre, The Royal Women's Hospital, Parkville, 3052, Australia.
⁹ Department of Obstetrics and Gynaecology, The University of Melbourne, Sunshine Hospital, St Albans, 3021, Australia; Maternal Fetal Medicine, Sunshine Hospital, Western Health, St Albans, 3021, Australia.
¹⁰ Department of Maternal-Fetal Medicine Pregnancy Research Centre, The Royal Women's Hospital, Parkville, 3052, Australia; Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, 3052, Australia; Department of Medicine, School of Clinical Sciences, Monash University, Clayton, 3168, Australia.

PMID: 30803713
DOI: 10.1016/j.placenta.2018.12.007

Decreased placental glypican expression is associated with human fetal growth restriction

T Gunatillake et al. Placenta. 2019.

. 2019 Jan 15:76:6-9.

doi: 10.1016/j.placenta.2018.12.007. Epub 2018 Dec 21.

Authors

Affiliations

¹ Department of Obstetrics and Gynaecology, The University of Melbourne, Sunshine Hospital, St Albans, 3021, Australia. Electronic address: gunatillake.t@unimelb.edu.au.
² Department of Obstetrics and Gynaecology, The University of Melbourne, Sunshine Hospital, St Albans, 3021, Australia.
³ Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, 3052, Australia.
⁴ Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, 3052, Australia; Department of Clinical Haematology, Royal Children's Hospital, Parkville, 3052, Australia.
⁵ Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, 3052, Australia; Department of Paediatrics, The University of Melbourne, Royal Children's Hospital, Parkville, 3052, Australia; Department of Clinical Haematology, Royal Children's Hospital, Parkville, 3052, Australia.
⁶ Graduate School of Biomedical Engineering, University of New South Wales, Kensington, Australia.
⁷ Department of Obstetrics and Gynaecology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.
⁸ Department of Maternal-Fetal Medicine Pregnancy Research Centre, The Royal Women's Hospital, Parkville, 3052, Australia.
⁹ Department of Obstetrics and Gynaecology, The University of Melbourne, Sunshine Hospital, St Albans, 3021, Australia; Maternal Fetal Medicine, Sunshine Hospital, Western Health, St Albans, 3021, Australia.
¹⁰ Department of Maternal-Fetal Medicine Pregnancy Research Centre, The Royal Women's Hospital, Parkville, 3052, Australia; Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, 3052, Australia; Department of Medicine, School of Clinical Sciences, Monash University, Clayton, 3168, Australia.

PMID: 30803713
DOI: 10.1016/j.placenta.2018.12.007

Abstract

Placental mediated fetal growth restriction (FGR) is a leading cause of perinatal morbidity and mortality. Heparan sulphate proteoglycans (HSPG) are highly expressed in placentae and regulate haemostasis. We hypothesise that altered expression of HSPGs, glypicans (GPC) may contribute to the development of FGR and small-for-gestational-age (SGA). GPC expression was determined in first-trimester chorionic villous samples collected from women with later SGA pregnancies and in placentae from third-trimester FGR and gestation-matched uncomplicated pregnancies. The expression of both GPC1 and GPC3 were significantly reduced in first-trimester SGA as well as in the third-trimester FGR placentae compared to controls. This is the first study to report a relationship between altered placental GPC expression and subsequent development of SGA/FGR.

Keywords: Fetal growth; Glypican; Heparan sulphate; Proteoglycans; Restriction.

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Decreased placental glypican expression is associated with human fetal growth restriction

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Decreased placental glypican expression is associated with human fetal growth restriction

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