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. 2019 Mar-Apr;33(2):587-594.
doi: 10.21873/invivo.11515.

Postoperative Level of C-Reactive Protein Is a Prognosticator After Esophageal Cancer Surgery With Perioperative Steroid Therapy and Enhanced Recovery After Surgery Care

Kazuki Kano #  1   2 , Toru Aoyama #  2 , Yukio Maezawa  2 , Tsutomu Hayashi  1   2 , Takanobu Yamada  1   2 , Hiroshi Tamagawa  2 , Tsutomu Sato  2 , Haruhiko Cho  2 , Takaki Yoshikawa  2 , Yasushi Rino  2 , Munetaka Masuda  2 , Takashi Oshima  3 , Takashi Ogata  3
Affiliations

Postoperative Level of C-Reactive Protein Is a Prognosticator After Esophageal Cancer Surgery With Perioperative Steroid Therapy and Enhanced Recovery After Surgery Care

Kazuki Kano et al. In Vivo. 2019 Mar-Apr.

Abstract

Background: This study investigated the impact of postoperative C-reactive protein (CRP) level on survival in patients with esophageal cancer who received perioperative steroid therapy and enhanced recovery after surgery (ERAS) care.

Patients and methods: Overall, 115 patients were retrospectively reviewed. The patients were classified into those with a high CRP level (≥4.0 mg/dl) on postoperative day 4 and those with low CRP level (<4.0 mg/dl). The risk factors for overall survival (OS) and recurrence-free survival (RFS) were identified.

Results: The OS and RFS rates at 5 years after surgery were significantly low in patients with high CRP level on postoperative day 4. The multivariate analysis demonstrated that high CRP level on postoperative day 4 was a significant independent risk factor for OS and RFS.

Conclusion: The present results suggest that the postoperative CRP level can be a prognosticator in patients with esophageal cancer who have received perioperative steroid therapy and ERAS care.

Keywords: C-reactive protein; Postoperative; enhanced recovery after surgery care; steroid therapy.

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Conflict of interest statement

The Authors declare no conflict of interest in regard to this study.

Figures

Figure 1
Figure 1. Flow diagram of the 153 patients who were given a diagnosis of clinical stage IB, IIA, IIB, IIIA, IIIB, or IIIC esophageal cancer between January 2011 and September 2015.
Figure 2
Figure 2. Kaplan–Meier curve for overall survival in patients with esophageal cancer according to C-reactive protein (CRP) level on postoperative day 4 (high CRP: ≥4.0 mg/dl, low CRP: < 4.0 mg/dl).
Figure 3
Figure 3. Kaplan–Meier curve for recurrence-free survival in patients with esophageal cancer according to C-reactive protein (CRP) level on postoperative day 4 (high CRP: ≥4.0 mg/dl, low CRP: < 4.0 mg/dl).
See this image and copyright information in PMC

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