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Comment
. 2019 May;18(5):429-431.
doi: 10.1038/s41563-019-0312-9.

Neuron-like neural probes

Jeffrey R Capadona  1   2 , Andrew J Shoffstall  3   4 , Joseph J Pancrazio  5
Affiliations
Comment

Neuron-like neural probes

Jeffrey R Capadona et al. Nat Mater. 2019 May.

Abstract

Neural probes that mimic the subcellular structural features and mechanical properties of neurons assimilate across several structures of the brain to provide chronically stable neural recordings in a mouse model.

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Figures

Fig. 1 |
Fig. 1 |. Bioinspired probes for neural recordings.
a, The neuron-like electronics (NeuE) technology (electrodes and interconnects in yellow, polymer layers in red) compared to the shape of a neuron (green). b, 3D histology showing a network of NeuE recording probes (red) interpenetrating neurons (green) two days after implantation. Scale bar, 100 μm. c, Action potentials from single neurons detected by five NeuE channels (shown in the different rows) over 90 days post-injection. For each channel, each colour shows spikes from the same neuron. d, 3D representation of the distribution of doublecortin (DCX+) newborn neurons (yellow) along NeuE (red) after one week from implantation. Blue represents the 4’,6-diamidino-2–310 phenylindole marker used to stain nuclear DNA. Reproduced from ref., Springer Nature Ltd.
See this image and copyright information in PMC

Comment on

  • Bioinspired neuron-like electronics.
    Yang X, Zhou T, Zwang TJ, Hong G, Zhao Y, Viveros RD, Fu TM, Gao T, Lieber CM. Yang X, et al. Nat Mater. 2019 May;18(5):510-517. doi: 10.1038/s41563-019-0292-9. Epub 2019 Feb 25. Nat Mater. 2019. PMID: 30804509 Free PMC article.

References

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    1. Yang X et al. Nat. Mater 10.1038/s41563-019-0292-9 (2019). - DOI - PubMed