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Case Reports
. 2019 Jan 20:2019:1482727.
doi: 10.1155/2019/1482727. eCollection 2019.

Acute Renal Failure Secondary to Inadvertent Propylene Glycol Overdose with Single-Day High-Dose Vitamin D (Stosstherapy)

David H Jelley  1 , Deborah Zayneb Mohamad Ali  2 , Michelle Condren  3
Affiliations
Case Reports

Acute Renal Failure Secondary to Inadvertent Propylene Glycol Overdose with Single-Day High-Dose Vitamin D (Stosstherapy)

David H Jelley et al. Case Rep Endocrinol. .

Abstract

Globally, there has been increasing attention paid to vitamin D deficiency and its treatment. Vitamin D stosstherapy with high-dose ergocalciferol in a single day is reemerging as a potential treatment option. We present an as yet unreported complication of acute renal injury due to propylene glycol toxicity in a 7-month infant treated with vitamin D stosstherapy. The product label for the vitamin D used for this patient states it is dissolved in propylene glycol (PG), but the amount is not listed on this or other US ergocalciferol liquid products that contain PG. Caution should be used when considering vitamin D stosstherapy with liquid ergocalciferol products available in the United States.

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Figure 1
Classic rachitic changes of the wrist: fraying and widening at the radial and ulnar metaphyses.
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References

    1. Harnapp G. O. Die Stossprophylaxe der Rachitis mit Vitamin D2 und D3. Journal of Molecular Medicine. 1938;17(11):390–391. doi: 10.1007/BF01781698. - DOI
    1. Chesney R. W. Vitamin D Deficiency and Rickets. Reviews in Endocrine and Metabolic Disorders. 2001;2(2):145–151. doi: 10.1023/A:1010071426415. - DOI - PubMed
    1. Mittal H., Rai S., Shah D., et al. 300,000 IU or 600,000 IU of oral vitamin D3 for treatment of nutritional rickets: A randomized controlled trial. Indian Pediatrics. 2014;51(4):265–272. doi: 10.1007/s13312-014-0399-7. - DOI - PubMed
    1. Shah B. R., Finberg L. Single-day therapy for nutritional vitamin D-deficiency rickets: A preferred method. Journal of Pediatrics. 1994;125(3):487–490. doi: 10.1016/S0022-3476(05)83303-7. - DOI - PubMed
    1. Markestad T., Hesse V., Siebenhuner M., et al. Intermittent high-dose vitamin D prophylaxis during infancy: Effect on vitamin D metabolites, calcium, and phosphorus. American Journal of Clinical Nutrition. 1987;46(4):652–658. doi: 10.1093/ajcn/46.4.652. - DOI - PubMed

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