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. 2019 Feb 5:9:28.
doi: 10.3389/fonc.2019.00028. eCollection 2019.

Prognostic and Risk Stratification Value of Lesion MACC1 Expression in Colorectal Cancer Patients

Aifen Lin  1 , Xia Zhang  1 , Rui-Li Zhang  2 , Xiao-Fang He  3 , Jian-Gang Zhang  1 , Wei-Hua Yan  4
Affiliations

Prognostic and Risk Stratification Value of Lesion MACC1 Expression in Colorectal Cancer Patients

Aifen Lin et al. Front Oncol. .

Abstract

The up-regulated metastasis-associated in colon cancer 1 (MACC1) expression and its clinical significance has been explored in a varity of malignancies. In this study, lesion MACC1 expression in 503 CRC patients (N colon = 332, N rectal = 171) were analyzed with immunohistochemistry, and its correlation with clinical parameters, patient survival, and its impact on prognostic stratification were evaluated. Data revealed the survival of patient with MACC1high is markedly worse than that of MACC1low (mean overall survival: 80.1 vs. 90.4 months; p = 0.001) and is an independent prognostic predictor (hazard ratio = 1.533; p = 0.005). More importantly, for the first time, we demonstrated that MACC1 status exhibited a significantly prognostic power for stratified clinical parameters such as patient age and gender, particular TNM status, and distinct AJCC disease stage. In summary, our findings indicated that MACC1 is a valuable prognostic and risk stratification biomarker for colorectal cancer patients.

Keywords: MACC1; colorectal cancer; prognosis; risk stratification; survival.

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Figures

Figure 1
Figure 1
(A) Representative immunohistochemistry staining of MACC1neg (index = 0), MACC1low (index = 0.75), and MACC1high (index = 1.96) expression in primary CRC sections. (B) The distribution of the index of MACC1 expression in CRC patients. The red line represents the cut-off value determined by ROC curve. The blue line represents the median of the index of MACC1 expression.
Figure 2
Figure 2
Kaplan-Meier survival analysis of the index of MACC1 expression with the median (0.950) for CRC patients. Comparison of overall survival between MACC1low and MACC1high among (A) all CRC patients; (B) colon cancer patients; and (C) rectal cancer patients.
Figure 3
Figure 3
Kaplan-Meier survival analysis between MACC1low and MACC1high with the median (0.950) in distinct AJCC stage CRC patients. CRC patients with AJCC (A) stage I; (B) stage II; (C) stage III, and (D) stage IV.
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