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. 2019 Aug 5;21(8):968-980.
doi: 10.1093/neuonc/noz022.

Molecular profiling and targeted therapy in pediatric gliomas: review and consensus recommendations

Zachary Miklja  1 , Amy Pasternak  2 , Stefanie Stallard  1 , Theodore Nicolaides  3 , Cassie Kline-Nunnally  4 , Bonnie Cole  5 , Rameen Beroukhim  6 , Pratiti Bandopadhayay  6 , Susan Chi  6 , Shakti H Ramkissoon  7   8 , Brendan Mullan  1 , Amy K Bruzek  1 , Angela Gauthier  9 , Taylor Garcia  1 , Christie Atchison  1 , Bernard Marini  2 , Maryam Fouladi  10 , D William Parsons  11 , Sarah Leary  5 , Sabine Mueller  4 , Keith L Ligon  12 , Carl Koschmann  1
Affiliations

Molecular profiling and targeted therapy in pediatric gliomas: review and consensus recommendations

Zachary Miklja et al. Neuro Oncol. .

Abstract

As the field of neuro-oncology makes headway in uncovering the key oncogenic drivers in pediatric glioma, the role of precision diagnostics and therapies continues to rapidly evolve with important implications for the standard of care for clinical management of these patients. Four studies at major academic centers were published in the last year outlining the clinically integrated molecular profiling and targeting of pediatric brain tumors; all 4 demonstrated the feasibility and utility of incorporating sequencing into the care of children with brain tumors, in particular for children and young adults with glioma. Based on synthesis of the data from these studies and others, we provide consensus recommendations for the integration of precision diagnostics and therapeutics into the practice of pediatric neuro-oncology. Our primary consensus recommendation is that next-generation sequencing should be routinely included in the workup of most pediatric gliomas.

Keywords: high-grade glioma; low-grade glioma; next-generation sequencing; pediatric; precision medicine.

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Figures

Fig. 1
Fig. 1
Schematic of key pathways in pediatric glioma, including the frequent efflux of drugs from CNS tissue by efflux proteins such as P-glycoprotein and breast cancer resistance protein
See this image and copyright information in PMC

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