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. 2019 Sep;234(9):16517-16525.
doi: 10.1002/jcp.28322. Epub 2019 Feb 25.

KIF20B promotes the progression of clear cell renal cell carcinoma by stimulating cell proliferation

Gang Li  1 , Zun-Ke Xie  1 , Dong-Sheng Zhu  1 , Tao Guo  1 , Qi-Liang Cai  1 , Yi Wang  1
Affiliations

KIF20B promotes the progression of clear cell renal cell carcinoma by stimulating cell proliferation

Gang Li et al. J Cell Physiol. 2019 Sep.

Abstract

Renal cell carcinoma (RCC) is a common urinary system cancer with high morbidity and mortality rate. Clear cell renal cell carcinoma (ccRCC) is a highly aggressive and common type of RCC. More and effective therapeutic targets are badly needed for the treatment of ccRCC. Kinesin family protein (KIF)20B, also named M-phase phosphoprotein 1, was reported as a microtubule-associated, plus-end-directed kinesin. KIF20B was involved in multiple cellular processes such as cytokinesis. Multiple studies indicated the oncogenic role for KIF20B in several types of tumors, including breast cancer and bladder cancer. However, the possible role of KIF20B in the progression of renal carcinoma is still unknown. Herein, our study demonstrated that KIF20B was relatively highly expressed in ccRCC tissues. In addition, KIF20B was inversely related to the clinical features including tumor size and T stage. We further found that inhibition of the KIF20B expression by a specific short hairpin RNA obviously reduces proliferation of ccRCC cells both in vitro and in vivo. Our study reveals the involvement of KIF20B in ccRCC progression. Generally, KIF20B is a promising novel therapeutic for the treatment of clear cell RCC.

Keywords: clear cell renal cell carcinoma (ccRCC); clinical features; kinesin family protein (KIF)20B; proliferation; therapeutic target.

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References

REFERENCES
    1. Abaza, A., Soleilhac, J. M., Westendorf, J., Piel, M., Crevel, I., Roux, A., & Pirollet, F. (2003). M phase phosphoprotein 1 is a human plus-end-directed kinesin-related protein required for cytokinesis. Journal of Biological Chemistry, 278(30), 27844-27852.
    1. Al-Qarqaz, F., Marji, M., Bodoor, K., Almomani, R., Al Gargaz, W., Alshiyab, D., … Alqudah, M. (2018). Clinical and demographic features of basal cell carcinoma in North Jordan. Journal of Skin Cancer, 2018, 2624054-2624055.
    1. Boussios, S., & Pavlidis, N. (2014). Renal cell carcinoma in pregnancy: A rare coexistence. Clinical and Translational Oncology, 16(2), 122-127.
    1. Chen, Y. W., Ornstein, M. C., Wood, L. S., Allman, K. D., Martin, A., Beach, J., … Rini, B. I. (2018). The association between facility case volume and overall survival in patients with metastatic renal cell carcinoma in the targeted therapy era. Urologic Oncology, 36(10), 470.e19-470.e29. e429.
    1. da Costa, W. H., da Cunha, I. W., Fares, A. F., Bezerra, S. M., Shultz, L., Clavijo, D. A., … Cassio Zequi, S. (2018a). Prognostic impact of concomitant loss of PBRM1 and BAP1 protein expression in early stages of clear cell renal cell carcinoma. Urologic Oncology, 36(5), 243-243.e8. e241-243 e248

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