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Comment
. 2019 May;15(5):932-933.
doi: 10.1080/15548627.2019.1586261. Epub 2019 Feb 27.

An autophagy-independent role for ATG16L1: promoting lysosome-mediated plasma membrane repair

Joel M J Tan  1   2 , Nora Mellouk  1 , John H Brumell  1   2   3   4
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Comment

An autophagy-independent role for ATG16L1: promoting lysosome-mediated plasma membrane repair

Joel M J Tan et al. Autophagy. 2019 May.

Abstract

There is growing evidence in the literature for unconventional roles of autophagy-related (ATG) proteins, outside of their function in canonical autophagy. Here we discuss our recent study that revealed a novel ATG16L1-dependent pathway that promotes plasma membrane repair upon bacterial pore-forming toxin damage. Disruption of the ATG16L1-dependent pathway leads to an accumulation of cholesterol in lysosomes, which affects lysosomal exocytosis required for efficient membrane repair. Our study provides insights into the role of ATG16L1 in cholesterol homeostasis and plasma membrane integrity.

Keywords: Autophagy; bacterial infection; cholesterol; inflammatory bowel disease; lysosome; plasma membrane repair.

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References

    1. Tan JMJ, Mellouk N, Osborne SE, et al. An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread. Nat Microbiol. 2018. December;3(12):1472–1485. - PubMed

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