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Review
. 2019 Oct-Dec;41(4):539-549.
doi: 10.1590/2175-8239-JBN-2018-0177.

Hepatitis C in Hemodialysis Units: diagnosis and therapeutic approach

[Article in English, Portuguese]
Natasha Silva Constancio  1   2 , Maria Lucia Gomes Ferraz  3   4 , Carmen Tzanno Branco Martins  2 , Angiolina Campos Kraychete  2 , Paulo Lisboa Bitencourt  4 , Marcelo Mazza do Nascimento  5   2
Affiliations
Review

Hepatitis C in Hemodialysis Units: diagnosis and therapeutic approach

[Article in English, Portuguese]
Natasha Silva Constancio et al. J Bras Nefrol. 2019 Oct-Dec.

Abstract
in English, Portuguese

According to data from the last census of the Brazilian Society of Nephrology (SBN), the prevalence of hepatitis C virus (HCV) in Brazilian hemodialysis units (HU) is 3.3%, about three times higher than what is reported for the Brazilian general population. Often, professionals working in HU are faced with clinical situations that require rapid HCV diagnosis in order to avoid horizontal transmission within the units. On the other hand, thanks to the development of new antiviral drugs, the cure of patients with HCV, both in the general population and in patients with chronic kidney disease and the disease eradication, appear to be very feasible objectives to be achieved in the near future . In this scenario, SBN and the Brazilian Society of Hepatology present in this review article a proposal to approach HCV within HUs.

De acordo com os dados do último censo da Sociedade Brasileira de Nefrologia (SBN), a prevalência de portadores do vírus da hepatite C (HCV) nas unidades de hemodiálise (UH) no Brasil é de 3,3%, cerca de três vezes maior do que é observado na população geral brasileira. Muitas vezes, os profissionais que trabalham nas UH deparam-se com situações clínicas que demandam rápido diagnóstico do HCV, a fim de evitar uma transmissão horizontal dentro das unidades. Por outro lado, a cura dos pacientes portadores do HCV, tanto na população geral como na portadora de doença renal crônica e a erradicação da doença, em virtude do desenvolvimento de novas drogas antivirais, parecem ser objetivos bastante factíveis, a ser alcançados em futuro próximo. Nesse cenário, a SBN e a Sociedade Brasileira de Hepatologia apresentam neste artigo de revisão uma proposta de abordagem do HCV dentro das UH.

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Figures

Figure 1
Figure 1. Hepatitis C virus genome and structure.
Figure 2
Figure 2. Initial HCV serological assessment flowchart after admission to the Dialysis Unit.
Figure 3
Figure 3. Follow-up serum flowchart in the Hemodialysis Unit.
Figure 4
Figure 4. Universal precaution measures for safety in dialysis Source: Centers for Disease Control and Prevention. Control, C.f.D. and prevention, dialysis safety: audit tools, protocols and checklists, 2013.
See this image and copyright information in PMC

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