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. 1986 Feb;83(3):701-5.
doi: 10.1073/pnas.83.3.701.

Molecular cloning, germ-line transformation, and transcriptional analysis of the zeste locus of Drosophila melanogaster

P H Gunaratne, A Mansukhani, S E Lipari, H C Liou, D W Martindale, M L Goldberg

Molecular cloning, germ-line transformation, and transcriptional analysis of the zeste locus of Drosophila melanogaster

P H Gunaratne et al. Proc Natl Acad Sci U S A. 1986 Feb.

Abstract

Approximately 170 kilobase pairs (kb) of contiguous DNA sequences derived from bands 3A3,4 of the Drosophila melanogaster X chromosome have been isolated by molecular cloning. Sequences required for the wild-type expression of the zeste locus are located within a 6-kb fragment of this chromosomal region, as shown by phenotypic rescue of zeste mutants in P element-mediated germ-line transformation. Expression of zeste is correlated with a 2.2-kb poly(A)+ RNA species transcribed at all postzygotic stages of Drosophila development. Many zeste alleles, including several producing neomorphic phenotypes, are not associated with detectable rearrangements of DNA.

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References

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